ArticleNature communications2015
Real-time tracking of cell cycle progression during CD8+ effector and memory T-cell differentiation.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed.
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- DeepKymoTracker: A tool for accurate construction of cell lineage trees for highly motile cells.PloS one · 2025Article
- GSH-responsive polymeric micelles-based augmented photoimmunotherapy synergized with PD-1 blockade for eliciting robust antitumor immunity against colon tumor.Journal of nanobiotechnology · 2024Article
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- Redox-responsive polymer micelles co-encapsulating immune checkpoint inhibitors and chemotherapeutic agents for glioblastoma therapy.Nature communications · 2024Article
- Monitoring Cell Proliferation by Dye Dilution: Considerations for Panel Design.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Identifying the roles of miR-17 in ciliogenesis and cell cycle.Frontiers in cell and developmental biology · 2024Article
- A mean-field description for the expansion kinetics of activated T cell populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Picking up speed: cell cycle regulation during effector CD8Medical microbiology and immunology · 2023Article
- Bacterial Metabolism-Initiated Nanocatalytic Tumor Immunotherapy.Nano-micro letters · 2022Article
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- Alpha radionuclide-chelated radioimmunotherapy promoters enable local radiotherapy/chemodynamic therapy to discourage cancer progression.Biomaterials research · 2022Article
- Short and long-term immune changes in different severity groups of COVID-19 disease.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Systems-level identification of key transcription factors in immune cell specification.PLoS computational biology · 2022Article
- Counting generations in birth and death processes with competing Erlang and exponential waiting times.Scientific reports · 2022Article
- Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy.iScience · 2022Article
- Enhancement of antitumor immunotherapy using mitochondria-targeted cancer cell membrane-biomimetic MOF-mediated sonodynamic therapy and checkpoint blockade immunotherapy.Journal of nanobiotechnology · 2022Article
19 more citing papers are in PubMed but not listed here.
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14 authors.
Funding
Abstract
The precise pathways of memory T-cell differentiation are incompletely understood. Here we exploit transgenic mice expressing fluorescent cell cycle indicators to longitudinally track the division dynamics of individual CD8(+) T cells. During influenza virus infection in vivo, naive T cells enter a CD62L(intermediate) state of fast proliferation, which continues for at least nine generations. At the peak of the anti-viral immune response, a subpopulation of these cells markedly reduces their cycling speed and acquires a CD62L(hi) central memory cell phenotype. Construction of T-cell family division trees in vitro reveals two patterns of proliferation dynamics. While cells initially divide rapidly with moderate stochastic variations of cycling times after each generation, a slow-cycling subpopulation displaying a CD62L(hi) memory phenotype appears after eight divisions. Phenotype and cell cycle duration are inherited by the progeny of slow cyclers. We propose that memory precursors cell-intrinsically modulate their proliferative activity to diversify differentiation pathways.
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