ArticleExperimental dermatology2015
PDGF signalling in the dermis and in dermal condensates is dispensable for hair follicle induction and formation.
Article in Experimental dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Deciphering the cellular landscape and genetic underpinnings of fiber diameter determined by dermal papilla cells in fine-wool sheep.Frontiers in cell and developmental biology · 2026Article
- Enhancing Mid-Upper Facial Contours: Hairline Transplant Solutions for East Asian Women With High and Wide Foreheads.Journal of cosmetic dermatology · 2025Article
- PDGFRα signaling regulates cartilage and fibrous tissue differentiation during synovial joint development.Nature communications · 2025Article
- Effects of photoperiod change on serum hormone level, hair follicle growth and antioxidant status in skin tissue of cashmere goats.Frontiers in veterinary science · 2025Article
- Duo-role Platelet-rich Plasma: temperature-induced fibrin gel and growth factors' reservoir for microneedles to promote hair regrowth.Journal of advanced research · 2024Article
- Integrating zinc/silicon dual ions with 3D-printed GelMA hydrogel promotesInternational journal of bioprinting · 2023Article
- Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12).International journal of molecular sciences · 2022Article
- Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing.Frontiers in medicine · 2022Review
- Amphiregulin promotes hair regeneration of skin-derived precursors via the PI3K and MAPK pathways.Cell proliferation · 2021Article
- HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cellsMolecular medicine reports · 2021Article
- Reconstructed human skin shows epidermal invagination towards integrated neopapillae indicating early hair follicle formation in vitro.Journal of tissue engineering and regenerative medicine · 2020Article
- An updated classification of hair follicle morphogenesis.Experimental dermatology · 2019Review
- PDGFA in Cashmere Goat: A Motivation for the Hair Follicle Stem Cells to Activate.Animals : an open access journal from MDPI · 2019Article
- Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation.eLife · 2018Article
- Minoxidil Promotes Hair Growth through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells.International journal of molecular sciences · 2018Article
- Defining Key Genes Regulating Morphogenesis of Apocrine Sweat Gland in Sheepskin.Frontiers in genetics · 2018Article
- Therapeutic Potential of Stem Cells in Follicle Regeneration.Stem cells international · 2018Review
- Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging.International journal of molecular sciences · 2017Review
- The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds).Stem cells international · 2017Review
- Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal.NPJ Regenerative medicine · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Embryonic hair follicle (HF) induction and formation is dependent on signalling crosstalk between the dermis and specialized dermal condensates on the mesenchymal side and epidermal cells and incipient placodes on the epithelial side, but the precise nature and succession of signals remain unclear. Platelet-derived growth factor (PDGF) signalling is involved in the development of several organs and the maintenance of adult tissues, including HF regeneration in the hair cycle. As both PDGF receptors, PDGFRα and PDGFRβ, are expressed in embryonic dermis and dermal condensates, we explored in this study the role of PDGF signalling in HF induction and formation in the developing skin mesenchyme. We conditionally ablated both PDGF receptors with Tbx18(Cre) in early dermal condensates before follicle formation, and with Prx1-Cre broadly in the ventral dermis prior to HF induction. In both PDGFR double mutants, HF induction and formation ensued normally, and the pattern of HF formation and HF numbers were unaffected. These data demonstrate that mesenchymal PDGF signalling, either in the specialized niche or broadly in the dermis, is dispensable for HF induction and formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.