ArticleDigestive diseases and sciences2015
Volatile Organic Compounds in Urine for Noninvasive Diagnosis of Malignant Biliary Strictures: A Pilot Study.
Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- A Novel Fiber-Optical Fabry-Perot Microtip Sensor for 2-Propanol.Sensors (Basel, Switzerland) · 2025Article
- Identifying novel biomarkers for biliary tract cancer based on volatile organic compounds analysis and machine learning.Frontiers in oncology · 2025Article
- The potential of volatile organic compounds to diagnose primary sclerosing cholangitis.JHEP reports : innovation in hepatology · 2024Article
- Identification of breath volatile organic compounds to distinguish pancreatic adenocarcinoma, pancreatic cystic neoplasm, and patients without pancreatic lesions.World journal of gastrointestinal oncology · 2024Article
- Identification of urinary volatile organic compounds as a potential non-invasive biomarker for esophageal cancer.Scientific reports · 2023Article
- Primary Sclerosing Cholangitis-Associated Cholangiocarcinoma: From Pathogenesis to Diagnostic and Surveillance Strategies.Cancers · 2023Review
- Pancreatic Cancer and Detection Methods.Biomedicines · 2023Review
- Review
- Recent Development on Determination of Low-LevelMolecules (Basel, Switzerland) · 2022Review
- Exhaled volatile organic compounds for cholangiocarcinoma diagnosis.Liver research (Beijing, China) · 2022Article
- Volatolomics in healthcare and its advanced detection technology.Nano research · 2022Review
- Bile-volatile organic compounds in the diagnostics of pancreatic cancer and biliary obstruction: A prospective proof-of-concept study.Frontiers in oncology · 2022Article
- A prediction model using 2-propanol and 2-butanone in urine distinguishes breast cancer.Scientific reports · 2021Article
- Liver Impairment-The Potential Application of Volatile Organic Compounds in Hepatology.Metabolites · 2021Review
- Biliary Strictures and Cholangiocarcinoma - Untangling a Diagnostic Conundrum.Frontiers in oncology · 2021Review
- Urinary Volatile Organic Compound Analysis for the Diagnosis of Cancer: A Systematic Literature Review and Quality Assessment.Metabolites · 2020Review
- Analysis of urinary VOCs using mass spectrometric methods to diagnose cancer: A review.Clinical mass spectrometry (Del Mar, Calif.) · 2020Review
- Detecting cholangiocarcinoma in patients with primary sclerosing cholangitis - The promise of DNA methylation and molecular biomarkers.JHEP reports : innovation in hepatology · 2020Review
- The Effects of Prebiotic Supplementation with OMNi-LOGiCNutrients · 2020Article
- Risk and Surveillance of Cancers in Primary Biliary Tract Disease.Gastroenterology research and practice · 2016Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe use of volatile organic compounds (VOCs) in bile was recently studied and appeared promising for diagnosis of malignancy. Noninvasive diagnosis of malignant biliary strictures by using VOCs in urine has not been studied.
aimTo identify potential VOCs in urine to diagnose malignant biliary strictures.
methodsIn this prospective cross-sectional study, urine was obtained immediately prior to ERCP from consecutive patients with biliary strictures. Selected-ion flow-tube mass spectrometry was used to analyze the concentration of VOCs in urine samples.
resultsFifty-four patients with biliary strictures were enrolled. Fifteen patients had malignant stricture [six cholangiocarcinoma (CCA) and nine pancreatic cancer], and 39 patients had benign strictures [10 primary sclerosing cholangitis (PSC) and 29 with benign biliary conditions including chronic pancreatitis and papillary stenosis]. The concentration of several compounds (ethanol and 2-propanol) was significantly different in patients with malignant compared with benign biliary strictures (p < 0.05). Using receiver operating characteristic curve analysis, we developed a model for the diagnosis of malignant biliary strictures adjusted for age and gender based on VOC levels of 2-propranol, carbon disulfide, and trimethyl amine (TMA). The model [-2.4191 * log(2-propanol) + 1.1617 * log(TMA) - 1.2172 * log(carbon disulfide)] ≥ 7.73 identified the patients with malignant biliary stricture [area under the curve (AUC = 0.83)], with 93.3 % sensitivity and 61.5 % specificity (p = 0.009). Comparing patients with CCA and PSC, the model [38.864 * log(ethane) - 3.989 * log(1-octene)] ≤ 169.9 could identify CCA with 80 % sensitivity and 100 % specificity (AUC = 0.9).
conclusionsMeasurement of VOCs in urine may diagnose malignant biliary strictures noninvasively.
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