ReviewCurrent oncology reports2015
Precision medicine in breast cancer: genes, genomes, and the future of genomically driven treatments.
Review in Current oncology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- A video intervention to improve patient understanding of tumor genomic testing in patients with cancer.Cancer medicine · 2024Article
- Patient Understanding of Tumor Genomic Testing: A Quality Improvement Effort.JCO oncology practice · 2023Review
- Identification of Differentially Expressed Mirna by Next Generation Sequencing in Locally Advanced Breast Cancer Patients of South Indian Origin.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Challenges and future of precision medicine strategies for breast cancer based on a database on drug reactions.Bioscience reports · 2019Review
- Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX.Oncotarget · 2018Article
- Making the right calls in precision oncology.Nature biotechnology · 2018Article
- Personomics: The Missing Link in the Evolution from Precision Medicine to Personalized Medicine.Journal of personalized medicine · 2017Article
- Variation in organ-specific PIK3CA and KRAS mutant levels in normal human tissues correlates with mutation prevalence in corresponding carcinomas.Environmental and molecular mutagenesis · 2017Article
- What is known about melatonin, chemotherapy and altered gene expression in breast cancer.Oncology letters · 2017Article
- Toward Precision Healthcare: Context and Mathematical Challenges.Frontiers in physiology · 2017Article
- Testing chemotherapy efficacy in HER2 negative breast cancer using patient-derived spheroids.Journal of translational medicine · 2016Article
- Patient Graph Deep Learning to Predict Breast Cancer Molecular Subtype.IEEE/ACM transactions on computational biology and bioinformaticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Remarkable progress in sequencing technology over the past 20 years has made it possible to comprehensively profile tumors and identify clinically relevant genomic alterations. In breast cancer, the most common malignancy affecting women, we are now increasingly able to use this technology to help specify the use of therapies that target key molecular and genetic dependencies. Large sequencing studies have confirmed the role of well-known cancer-related genes and have also revealed numerous other genes that are recurrently mutated in breast cancer. This growing understanding of patient-to-patient variability at the genomic level in breast cancer is advancing our ability to direct the appropriate treatment to the appropriate patient at the appropriate time--a hallmark of "precision cancer medicine." This review focuses on the technological advances that have catalyzed these developments, the landscape of mutations in breast cancer, the clinical impact of genomic profiling, and the incorporation of genomic information into clinical care and clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.