Evidence map›Paper›PMID 25708756›Full record

ArticleGastrointestinal endoscopy2015

Good is better than excellent: bowel preparation quality and adenoma detection rates.

Audrey H Calderwood, Katherine D Thompson, Paul C Schroy, David A Lieberman, Brian C Jacobson

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Gastrointestinal endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Is water exchange superior to water immersion for colonoscopy? A systematic review and meta-analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Pooled it
  4. Trial
  5. Trial
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  8. Observational
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  11. Response to JS Li et al.Journal of gastroenterology · 2024
    Article
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  16. Article
  17. Bowel cleansing efficacy of 1 L NER1006JGH open : an open access journal of gastroenterology and hepatology · 2022
    Article
  18. Increased quality of bowel preparation via smartphone WeChat application: a multicenter randomized controlled trial.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Audrey H CalderwoodSection of Gastroenterology, Boston Medical Center, Boston, Massachusetts, USA.
Katherine D ThompsonDepartment of Medicine, Boston Medical Center, Boston, Massachusetts, USA.
Paul C SchroySection of Gastroenterology, Boston Medical Center, Boston, Massachusetts, USA.
David A LiebermanDivision of Gastroenterology, Oregon Health & Science University, Portland, Oregon, USA.
Brian C JacobsonSection of Gastroenterology, Boston Medical Center, Boston, Massachusetts, USA.
Boston Medical Center · USOregon Health & Science University · US

Funding

National Endoscopic Database of the Clinical Outcomes Research InitiativeU01DK057132 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI LIEBERMAN, DAVID A · 1999 to 2014
$12.7M
CORI: Consortium Expansion and Database EnhancementR33DK061778 · NIDDK · OREGON HEALTH AND SCIENCE UNIVERSITY · PI LIEBERMAN, DAVID A · 2002 to 2004
$1.4M
A Novel Colonoscopy Bowel Preparation Scale: Education, Validation, and UtilityK08DK090150 · NIDDK · BOSTON MEDICAL CENTER · PI CALDERWOOD, AUDREY HONG · 2011 to 2015
$711k
Colonoscopy in Rural Oregon Practice (CROP)R21CA131626 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LIEBERMAN, DAVID A · 2008 to 2009
$381k
NCI NIH HHS R21 CA131626NIDDK NIH HHS K08 DK090150NIDDK NIH HHS R33 DK061778NIDDK NIH HHS U01 DK057132
6 · The paper itself

Abstract

backgroundInadequate bowel cleansing is associated with missed lesions, yet whether polyp and adenoma detection rates (PDR, ADR) increase at the highest levels of bowel cleanliness is unknown.

objectiveTo evaluate the association between bowel preparation quality by using the Boston Bowel Preparation Scale (BBPS) and PDR and ADR among colonoscopies with adequate preparation.

designCross-sectional analysis.

settingBoston Medical Center (BMC) and the Clinical Outcomes Research Initiative (CORI). PATIENTS: Average-risk ambulatory patients attending screening colonoscopy with adequate bowel preparation defined as BBPS score ≥6.

interventionsColonoscopy. MAIN OUTCOME MEASUREMENTS: PDR and ADR stratified by BBPS score.

resultsAmong the 3713 colonoscopies at BMC performed by 19 endoscopists, the PDR, ADR, and advanced ADR were 49.8%, 37.7%, and 6.0%, respectively. Among the 5532 colonoscopies in CORI performed by 85 endoscopists at 41 different sites, the PDR was 44.5%, and the PDR for polyps >9 mm (surrogate for advanced ADR) was 6.2%. The PDR associated with total BBPS scores of 6, 7, and 8 were higher than those associated with a BBPS score of 9 at BMC (BBPS 6, 51%; BBPS 7, 53%; BBPS 8, 52% vs BBPS 9, 46%; P = .002) and CORI (BBPS 6, 51%; BBPS 7, 48%; BBPS 8, 45% vs BBPS 9, 40%; P < .0001). This trend persisted after we adjusted for age, sex, and race and/or ethnicity and was observed for ADR and advanced ADR. PDR was higher among good compared with excellent preparations at BMC (odds ratio [OR] 1.3; 95% confidence interval [CI], 1.0-1.5) and CORI (OR 4.7; 95% CI, 3.1-7.1). LIMITATIONS: Retrospective study.

conclusionThe PDR and ADR decreased at the highest levels of bowel cleanliness. Endoscopists finding a pristine bowel preparation should avoid a sense of overconfidence for polyp detection during the inspection phase of screening colonoscopy and still perform a careful evaluation for polyps. Furthermore, endoscopists expending additional effort to maximize cleansing of the bowel should never sacrifice on their inspection technique or inspection time.

Indexed as

CatharticsAdenomaAdultAgedColonic PolypsColonoscopyColorectal NeoplasmsCross-Sectional StudiesFemaleHumansLogistic ModelsMaleMiddle AgedOdds RatioRetrospective StudiesCathartics

Identifiers

PMID25708756
PMCPMC4339796
OpenAlexW2086735047

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.