Evidence map›Paper›PMID 25708717›Full record

ArticleBreast (Edinburgh, Scotland)2015

Adjusting the frequency of mammography screening on the basis of genetic risk: Attitudes among women in the UK.

Susanne F Meisel, Nora Pashayan, Belinda Rahman, Lucy Side, Lindsay Fraser, Sue Gessler, Anne Lanceley, Jane Wardle

Abstract read
In one paragraph

Article in Breast (Edinburgh, Scotland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Acceptability of risk stratification within population-based cancer screening from the perspective of the general public: A mixed-methods systematic review.Health expectations : an international journal of public participation in health care and health policy · 2023
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
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  9. Patients' Attitude toward Less Frequent Surveillance of Low-Risk Pancreatic Cysts: A Multicenter European Cohort Study.Medical decision making : an international journal of the Society for Medical Decision Making · 2025
    Observational
  10. Article
  11. Article
  12. Risk-Adapted Breast Screening for Women at Low Predicted Risk of Breast Cancer: An Online Discrete Choice Experiment.Medical decision making : an international journal of the Society for Medical Decision Making · 2024
    Article
  13. Article
  14. Article
  15. Risk-Stratified Screening for Colorectal Cancer Using Genetic and Environmental Risk Factors: A Cost-Effectiveness Analysis Based on Real-World Data.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Article
  16. Article
  17. Article
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  20. A community jury study exploring the public acceptability of using risk stratification to determine eligibility for cancer screening.Health expectations : an international journal of public participation in health care and health policy · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Susanne F MeiselHealth Behaviour Research Centre, Dept. Epidemiology and Public Health, University College London, London, UK. Electronic address: susanne.meisel@ucl.ac.uk.
Nora PashayanDept. of Applied Health Research, University College London, London, UK.
Belinda RahmanDept. of Women's Cancer, EGA UCL Institute for Women's Health, University College London, London, UK.
Lucy SideDept. of Women's Cancer, EGA UCL Institute for Women's Health, University College London, London, UK.
Lindsay FraserDept. of Women's Cancer, EGA UCL Institute for Women's Health, University College London, London, UK.
Sue GesslerDept. of Women's Cancer, EGA UCL Institute for Women's Health, University College London, London, UK.
Anne LanceleyDept. of Women's Cancer, EGA UCL Institute for Women's Health, University College London, London, UK.
Jane WardleHealth Behaviour Research Centre, Dept. Epidemiology and Public Health, University College London, London, UK.

Funding

Cancer Research UK 12677Cancer Research UK 13065Cancer Research UK 509050
6 · The paper itself

Abstract

purposeTo explore public attitudes towards modifying frequency of mammography screening based on genetic risk.

methodsHome-based interviews were carried out with a population-based sample of 942 women aged 18-74 years in the UK. Demographic characteristics and perceived breast cancer (BC) risk were examined as predictors of support for risk-stratified BC screening and of the acceptability of raised or lowered screening frequency based on genetic risk, using multivariate logistic regression.

resultsOver two-thirds of respondents (65.8%) supported the idea of varying screening frequency on the basis of genetic risk. The majority (85.4%) were willing to have more frequent breast screening if they were found to be at higher risk, but fewer (58.8%) were willing to have less frequent screening if at lower risk (t (956) = 15.6, p < 0.001). Ethnic minority status was associated with less acceptability of more frequent screening (OR = 0.40, 95% CI = 0.21-0.74), but there were no other significant demographic correlates. Higher perceived risk of BC was associated with greater acceptability of more frequent screening (OR = 1.71, 95%CI = 1.27-2.30).

conclusionWomen were positive about adjusting the frequency of mammography screening in line with personal genetic risk, but it will be important to develop effective communication materials to minimise resistance to reducing screening frequency for those at lower genetic risk.

Indexed as

Health Knowledge, Attitudes, PracticeAdolescentAdultAgedBreast NeoplasmsEarly Detection of CancerFemaleGenetic Predisposition to DiseaseHumansLogistic ModelsMammographyMiddle AgedRisk FactorsSurveys and QuestionnairesTime FactorsUnited KingdomBreast cancerPopulation surveyStratified screeningWomen's attitude

Identifiers

PMID25708717
PMCPMC4427278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.