ArticleMolecular neurobiology2016
The Pronociceptive Effect of Paradoxical Sleep Deprivation in Rats: Evidence for a Role of Descending Pain Modulation Mechanisms.
Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Effect of sleep loss on pain-New conceptual and mechanistic avenues.Frontiers in neuroscience · 2022Pooled it
- Experimental sleep disruption attenuates morphine analgesia: findings from a randomized trial and implications for the opioid abuse epidemic.Scientific reports · 2020Trial
- Potential modulation of pain perception in animal models of acute sleep deprivation: implications of different stress response mechanisms.The journal of headache and pain · 2026Article
- Why sleep matters in chronic pain: evidence across the lifespan.EBioMedicine · 2026Review
- Administration of the Sleep-Promoting Neuromodulator Adenosine Into the Median Preoptic and Septal Region Produced Thermal Hyperalgesia.Journal of sleep research · 2026Article
- Insomnia Increases Susceptibility to Sciatica: Evidence from Mendelian Randomization and Integrative Genetic Analyses.Journal of pain research · 2026Article
- TNF-α Enhanced Activity of Sympathetic Neurons in Superior Cervical Ganglion to Promote Chronic Sleep Deprivation-Related Hyperalgesia.Molecular neurobiology · 2025Article
- Article
- A New Pathway Mediating Pain Sensitization after Active Sleep Deprivation.Neuroscience bulletin · 2025Article
- At the Intersection of Pain and Sleep: a Roadmap for Preclinical Pain Research.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- What Links Sleep and Neuropathic Pain?: A Literature Review on the Neural Circuits for Sleep and Pain Control.Nature and science of sleep · 2025Review
- Modulating the Pronociceptive Effect of Sleep Deprivation: A Possible Role for Cholinergic Neurons in the Medial Habenula.Neuroscience bulletin · 2024Article
- Changes in the analgesic mechanism of oxytocin can contribute to hyperalgesia in Parkinson's disease model rats.PloS one · 2024Article
- Sleep behavior traits and associations with opioid-related adverse events: a cohort study.Sleep · 2023Article
- The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain.Nature and science of sleep · 2023Review
- Analgesic efficacy of sleep-promoting pharmacotherapy in patients with chronic pain: a systematic review and meta-analysis.Pain reports · 2023Review
- Preoperative Acute Sleep Deprivation Causes Postoperative Pain Hypersensitivity and Abnormal Cerebral Function.Neuroscience bulletin · 2022Article
- Pain thresholds and suprathreshold pain after sleep restriction in migraine - A blinded crossover study.Cephalalgia : an international journal of headache · 2022Article
- Causal association of sleep disturbances and low back pain: A bidirectional two-sample Mendelian randomization study.Frontiers in neuroscience · 2022Article
- Bidirectional Relationship between Opioids and Disrupted Sleep: Putative Mechanisms.Molecular pharmacology · 2020Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms underlying the pronociceptive effect of paradoxical sleep deprivation (PSD) are not known. In this study, we asked whether PSD increases tonic nociception in the formalin test, decreases the antinociceptive effect of morphine administered into the periaqueductal gray matter (PAG), and disrupts endogenous descending pain modulation. PSD for either 24 or 48 h significantly increased formalin-induced nociception and decreased mechanical nociceptive paw withdrawal threshold. The maximal antinociceptive effect induced by morphine (0.9-9 nmol, intra-PAG) was significantly decreased by PSD. The administration of a low dose of the GABAA receptor antagonist, bicuculline (30-300 pmol, intra-PAG), decreased nociception in control rats, but not in paradoxical-sleep-deprived ones. Furthermore, the administration of the cholecystokinin (CCK) 2 receptor antagonist, YM022 (0.5-2 pmol) in the rostral ventral medulla (RVM), decreased nociception in paradoxical-sleep-deprived rats but not in control ones. While a dose of the CCK 2 receptor agonist, CCK-8 (8-24 pmol intra-RVM), increased nociception in control rats, but not in paradoxical-sleep-deprived ones. In addition, the injection of lidocaine (QX-314, 2%, intra-RVM) decreased nociception in sleep-deprived rats, but not in control rats, while the lesion of the dorsolateral funiculus prevented the pronociceptive effect of PSD. Finally, PSD significantly increased c-Fos expression in the RVM. Therefore, PSD increases pain independently of its duration or of the characteristic of the nociceptive stimulus and decreases morphine analgesia at the PAG. PSD appears to increase pain by decreasing descending pain inhibitory activity and by increasing descending pain facilitatory activity.
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