ArticleScientific reports2015
Genetic variants in the Hippo pathway predict biochemical recurrence after radical prostatectomy for localized prostate cancer.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Structure-Based Virtual Screening andACS omega · 2026Article
- Exploring Genetic Contributions to Prostate Cancer Risk in an Asian Population-Based Study.Cancer medicine · 2026Article
- Interplay of Developmental Hippo-Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer.Cells · 2022Review
- TNFRSF13B is a potential contributor to prostate cancer.Cancer cell international · 2022Article
- Genetic variant located on chromosome 17p12 contributes to prostate cancer onset and biochemical recurrence.Scientific reports · 2022Article
- Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.Journal of medicinal chemistry · 2022Article
- Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study.The Journal of international medical research · 2021Article
- Genetic Analysis Reveals a Significant Contribution ofCancers · 2020Article
- Genetic association analysis identifies a role for ANO5 in prostate cancer progression.Cancer medicine · 2020Article
- Prognostic Value ofInternational journal of environmental research and public health · 2019Article
- Effect of genetic variants in cell adhesion pathways on the biochemical recurrence in prostate cancer patients with radical prostatectomy.Cancer medicine · 2019Article
- A common regulatory variant in SLC35B4 influences the recurrence and survival of prostate cancer.Journal of cellular and molecular medicine · 2018Article
- Cancer Stem Cell Gene Variants Predict Disease Recurrence in Patients Treated with Radical Prostatectomy for Prostate Cancer.International journal of medical sciences · 2017Article
- Association of HMGB1 Gene Polymorphisms with Risk of Colorectal Cancer in a Chinese Population.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Prognostic significance of fibroblast growth factor receptor 4 polymorphisms on biochemical recurrence after radical prostatectomy in a Chinese population.Scientific reports · 2016Article
- Genetic variants in ultraconserved regions associate with prostate cancer recurrence and survival.Scientific reports · 2016Article
- Molecular Pathways: Hippo Signaling, a Critical Tumor Suppressor.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- Genetic Association Analysis of Cell Cycle Regulators RevealsCancer genomics & proteomicsArticle
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While localized prostate cancer is potentially curative, many patients still show biochemical recurrence (BCR) after curative treatments such as radical prostatectomy (RP). The Hippo pathway has recently been shown to be an evolutionarily conserved regulator of tissue growth, and its perturbation can trigger tumorigenesis. We hypothesize that genetic variants of the Hippo pathway may influence clinical outcomes in localized prostate cancer patients. We genotyped 53 tagging single-nucleotide polymorphisms (SNPs) from seven core Hippo pathway genes in 246 localized prostate cancer patients treated with RP. Kaplan-Meier analysis and Cox proportional hazard models were utilized to identify significant SNPs that correlated with BCR. For replication, five associated SNPs were genotyped in an independent cohort of 212 patients. After adjusting for known clinicopathologic factors, the association between STK3 rs7827435 and BCR (P = 0.018) was replicated in the second stage (P = 0.026; Pcombined = 0.001). Additional integrated in silico analysis provided evidence that rs7827435 affects STK3 expression, which in turn is significantly correlated with tumor aggressiveness and patient prognosis. In conclusion, genetic variants of the Hippo pathway contribute to the variable outcomes of prostate cancer, and the discovery of these biomarkers provides a molecular approach for prognostic risk assessment.
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