ArticleClinical cardiology2015
Left ventricular diastolic dysfunction and E/E' ratio as the strongest echocardiographic predictors of reduced exercise capacity after acute myocardial infarction.
Article in Clinical cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Six-minute walk test: prognostic value and effects of nebivolol versus placebo in elderly patients with heart failure from the SENIORS trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Trial
- Discontinuous Doppler-Derived Intrarenal Venous Flow Is a Predictor of Impaired Exercise Capacity Associated With Poor Prognosis in Patients With Acute Coronary Syndrome.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Investigation of Skeletal Muscle Indices Affecting Anaerobic Thresholds after Acute Myocardial Infarction.Physical therapy research · 2024Article
- Cross-sectional associations between questionnaire-measured physical activity and tissue doppler indices of left ventricular diastolic function.BMC cardiovascular disorders · 2023Article
- Development of a prediction model for exercise tolerance decline in the exercise assessment of patients with acute myocardial infarction undergoing percutaneous coronary intervention revascularization in the acute phase.Journal of thoracic disease · 2023Article
- Cardioprotection Attributed to Aerobic Exercise-Mediated Inhibition of ALCAT1 and Oxidative Stress-Induced Apoptosis in MI Rats.Biomedicines · 2022Article
- Peri-operative changes in diastolic function and outcomes in congenital aortic valve surgery.Echocardiography (Mount Kisco, N.Y.) · 2022Article
- Brown adipose tissue prevents glucose intolerance and cardiac remodeling in high-fat-fed mice after a mild myocardial infarction.International journal of obesity (2005) · 2022Article
- Determinants of Exercise Capacity Following ST-Elevation Myocardial Infarction (STEMI).Journal of cardiovascular development and disease · 2021Article
- Mechanisms of Exercise Capacity Improvement after Cardiac Rehabilitation Following Myocardial Infarction Assessed with Combined Stress Echocardiography and Cardiopulmonary Exercise Testing.Journal of clinical medicine · 2021Article
- Article
- Reduced exercise capacity and clinical outcomes following acute myocardial infarction.Heart and vessels · 2020Observational
- Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients.BMC cardiovascular disorders · 2020Article
- Association between baseline cardiovascular mechanics and exercise capacity in patients with coronary artery disease.Anatolian journal of cardiology · 2016Article
- Impaired Diastolic Recovery after Acute Myocardial Infarction as a Predictor of Adverse Events.Journal of cardiovascular ultrasound · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mechanisms that determine reduced exercise capacity after acute myocardial infarction (AMI) are not fully understood, especially the relative role of left ventricular diastolic and systolic function. HYPOTHESIS: To evaluate the role of different diastolic and systolic function echocardiographic parameters as predictors of reduced functional capacity in patients after AMI.
methodsOne month after AMI, 225 patients (84% male; mean age, 55.1 ± 10.9 years) were enrolled and underwent detailed echocardiography and cardiopulmonary exercise test on the same day. Systolic and diastolic function was evaluated by echocardiography according to the latest consensus recommendations, including tissue Doppler evaluation. Exercise capacity was evaluated with peak oxygen consumption (VO(2)).
resultsPeak VO(2) was significantly correlated with early diastolic tissue Doppler velocity (E') septal (r = 0.42, P < 0.001), E' lateral (r = 0.35, P < 0.001), septal E/E' ratio (r = -0.35, P = 0.001), and lateral E/E' (r = -0.27, P < 0.001). These diastolic function parameters predicted impaired exercise capacity (VO(2) <19 mL/kg/min), with an area under the receiver operating characteristic curve of 0.77 (95% confidence interval [CI]: 0.68-0.86, P < 0.001) for septal E/E'. On multivariate analysis, for each unit increase in septal E/E' ratio there was a -0.35 (95% CI: -0.54 to -0.15) mL/kg/min decrease in peak VO(2) independently of age, sex, body mass index, hypertension, and diabetes. There was a mild correlation between peak VO(2) and systolic function parameters (r = 0.17, P = 0.01 with ejection fraction; and r = 0.23, P = 0.02 with lateral systolic tissue Doppler velocity) that persisted after multivariate adjustment.
conclusionsAfter AMI, resting diastolic function parameters were the strongest correlates of exercise tolerance. Septal E/E' ratio was the best echocardiographic predictor of reduced functional capacity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.