Trial reportObesity (Silver Spring, Md.)2015
Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: the look AHEAD study.
Trial report in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05275608 (Effects of Very Low Calorie Ketogenic Diet on Microbiota, Adipose Tissue and Immunitary Regulation), which is not on this map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Very Low Calorie Ketogenic Diet on Microbiota, Adipose Tissue and Immunitary Regulation: Pilot Study on Patients with Metabolic Syndrome
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Different Exercises Combined with Different Dietary Interventions on Body Composition: A Systematic Review and Network Meta-Analysis.Nutrients · 2024Pooled it
- Long-term change in body composition following intentional weight loss and its effect on physical function.International journal of obesity (2005) · 2026Trial
- Associations of modifiable lifestyle and clinical factors with cognitive function in adults with type 2 diabetes.Journal of diabetes and its complications · 2026Trial
- Association Between Changes in Body Composition and Physical Function After Intensive Behavioral Weight-loss Intervention: A Look AHEAD Trial Subgroup Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Trial
- Associations between decreases in adiposity and reductions in HbA1c and insulin use in the Look AHEAD cohort.Obesity (Silver Spring, Md.) · 2025Trial
- Long-term sustained effects of the Look AHEAD lifestyle intervention on body composition among adults with type 2 diabetes.Obesity (Silver Spring, Md.) · 2024Trial
- Trial
- Effect of a tailored home-based exercise program in patients with systemic sclerosis: A randomized controlled trial.Scandinavian journal of medicine & science in sports · 2020Trial
- Novel Smartphone Game Improves Physical Activity Behavior in Type 2 Diabetes.American journal of preventive medicine · 2019Trial
- Physical Function Following a Long-Term Lifestyle Intervention Among Middle Aged and Older Adults With Type 2 Diabetes: The Look AHEAD Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Trial
- Impact of Intensive Lifestyle Intervention on Disability-Free Life Expectancy: The Look AHEAD Study.Diabetes care · 2018Trial
- The Effect of Intentional Weight Loss on Fracture Risk in Persons With Diabetes: Results From the Look AHEAD Randomized Clinical Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Trial
- Changes in skeletal muscle and organ size after a weight-loss intervention in overweight and obese type 2 diabetic patients.The American journal of clinical nutrition · 2017Trial
- The relationship of fasting hyperglycemia to changes in fat and muscle mass after exercise training in type 2 diabetes.Diabetes research and clinical practice · 2016Trial
- Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial.BMC medicine · 2016Trial
- Association of Weight Loss Maintenance and Weight Regain on 4-Year Changes in CVD Risk Factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial.Diabetes care · 2016Trial
- Legacy effects of short-term intentional weight loss on total body and thigh composition in overweight and obese older adults.Nutrition & diabetes · 2016Trial
- Weight loss lifestyle intervention and bone health hormonal markers in type 2 diabetes: analysis from look AHEAD study.Journal of the Endocrine Society · 2026Article
- Article
- Humans with function-disrupting variants in the myostatin gene (MSTN) have increased skeletal muscle mass and strength, and less adiposity.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
objectiveTo determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years.
methodsBody composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education.
resultsAt 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points.
conclusionsReduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.