Evidence map›Paper›PMID 25707374›Full record

ArticleScientific reports2015

Potential dual imaging nanoparticle: Gd2O3 nanoparticle.

Md Wasi Ahmad, Wenlong Xu, Sung June Kim, Jong Su Baeck, Yongmin Chang, Ji Eun Bae, Kwon Seok Chae, Ji Ae Park, Tae Jeong Kim, Gang Ho Lee

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 148 citations in OpenAlex.

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  12. New GdInternational journal of molecular sciences · 2022
    Article
  13. Article
  14. Special Issue "Advanced Nanomaterials for Bioimaging".Nanomaterials (Basel, Switzerland) · 2022
    Article
  15. GdProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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  18. Article
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  20. Radioprotective garment-inspired biodegradable polymetal nanoparticles for enhanced CT contrast production.Chemistry of materials : a publication of the American Chemical Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Md Wasi AhmadDepartment of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, South Korea.
Wenlong XuDepartment of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, South Korea.
Sung June KimDepartment of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, South Korea.
Jong Su BaeckDepartment of Molecular Medicine and Medical &Biological Engineering, School of Medicine, KNU, Taegu 702-701, South Korea.
Yongmin Chang1] Department of Molecular Medicine and Medical &Biological Engineering, School of Medicine, KNU, Taegu 702-701, South Korea [2] Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, South Korea.
Ji Eun BaeDepartment of Nanoscience and Nanotechnology, KNU, Taegu 702-701, South Korea.
Kwon Seok Chae1] Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, South Korea [2] Department of Biology Education, Teacher's College, KNU, Taegu 702-701, South Korea.
Ji Ae ParkLaboratory of Nuclear Medicine Research, Molecular Imaging Research Center, Korea Institute of Radiological Medical Science, Nowon-gil 75, Seoul 139-706, South Korea.
Tae Jeong KimInstitute of Biomedical Engineering Research, Kyungpook National University, Taegu 702-701, South Korea.
Gang Ho Lee1] Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, South Korea [2] Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, South Korea.
Kyungpook National University · KRKorea Institute of Radiological and Medical Sciences · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gadolinium (Gd) is a unique and powerful element in chemistry and biomedicine which can be applied simultaneously to magnetic resonance imaging (MRI), X-ray computed tomography (CT), and neutron capture therapy for cancers. This multifunctionality can be maximized using gadolinium oxide (Gd2O3) nanoparticles (GNPs) because of the large amount of Gd per GNP, making both diagnosis and therapy (i.e., theragnosis) for cancers possible using only GNPs. In this study, the T1 MRI and CT dual imaging capability of GNPs is explored by synthesizing various iodine compound (IC) coated GNPs (IC-GNPs). All the IC-GNP samples showed stronger X-ray absorption and larger longitudinal water proton relaxivities (r1 = 26-38 s(-1) mM(-1) and r2/r1 = 1.4-1.9) than the respective commercial contrast agents. In vivo T1 MR and CT images of mice were also acquired, supporting that the GNP is a potential dual imaging agent.

Identifiers

PMID25707374
PMCPMC4338476
OpenAlexW2087061090

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.