Evidence map›Paper›PMID 25707279›Full record

ReviewMethods in enzymology2015

Clocks and cardiovascular function.

Sarah C McLoughlin, Philip Haines, Garret A FitzGerald

Open access · greenAbstract readReview
In one paragraph

Review in Methods in enzymology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Circadian Rhythms, Disease and Chronotherapy.Journal of biological rhythms · 2021
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Interplay between Microbes and the Circadian Clock.Cold Spring Harbor perspectives in biology · 2018
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sarah C McLoughlinInstitute for Translational Medicine and Therapeutics, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Philip HainesInstitute for Translational Medicine and Therapeutics, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Garret A FitzGeraldInstitute for Translational Medicine and Therapeutics, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: garret@upenn.edu.
Translational Therapeutics (United States) · USUniversity of Pennsylvania · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3M
Multiscale Analysis of Inter-Clock CommunicationR01HL097800 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A, HOGENESCH, JOHN B · 2009 to 2012
$2.0M
NHLBI NIH HHS R01 HL097800NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

Circadian clocks in central and peripheral tissues enable the temporal synchronization and organization of molecular and physiological processes of rhythmic animals, allowing optimum functioning of cells and organisms at the most appropriate time of day. Disruption of circadian rhythms, from external or internal forces, leads to widespread biological disruption and is postulated to underlie many human conditions, such as the incidence and timing of cardiovascular disease. Here, we describe in vivo and in vitro methodology relevant to studying the role of circadian rhythms in cardiovascular function and dysfunction.

Indexed as

Cardiovascular Physiological PhenomenaCircadian RhythmAnimalsCells, CulturedHumansMacrophages, PeritonealMiceMyocytes, CardiacRadio WavesTelemetryThrombosisAtherosclerosisBlood pressureBMAL1Cardiovascular functionCircadian rhythmsClocksInflammationThrombosis

Identifiers

PMID25707279
PMCPMC4765173
OpenAlexW2396875738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.