ArticlePloS one2015
The risk of cancer in patients with congenital heart disease: a nationwide population-based cohort study in Taiwan.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Risk of Cancer in Patients with Congenital Heart Disease: A Systematic Review and Meta-Analysis.Cardiology · 2025Pooled it
- Structural birth defects and leukemia risk in children with Down syndrome.Scientific reports · 2025Article
- Risk of malignancy in adult patients with congenital heart disease: a clinical practice review.Cardiovascular diagnosis and therapy · 2025Review
- Cancer mortality in children surviving congenital heart interventions: A study from the Pediatric Cardiac Care Consortium.Pediatric blood & cancer · 2024Article
- Cumulative Radiation Exposure and Lifetime Cancer Risk in Patients With Tetralogy of Fallot Requiring Early Intervention.JACC. Advances · 2024Article
- Heart failure in patients with congenital heart disease after a cancer diagnosis.ESC heart failure · 2024Article
- Outcomes after cancer diagnosis in children and adult patients with congenital heart disease in Sweden: a registry-based cohort study.BMJ open · 2024Article
- CanCHD Study of Hematopoietic Cancers in Children With and Without Genetic Syndromes.Journal of the American Heart Association · 2024Article
- Outcomes following major thoracoabdominal cancer resection in adults with congenital heart disease.PloS one · 2024Article
- Prognosis of Chronic Kidney Disease and Metabolic Syndrome in Adults With Congenital Heart Disease.Journal of Korean medical science · 2023Article
- Cancer risk in adult congenital heart disease.International journal of cardiology. Congenital heart disease · 2023Review
- Outcomes of malignancy in adults with congenital heart disease: a single center experience.Cardio-oncology (London, England) · 2022Article
- Congenital Heart Disease and the Risk of Cancer: An Update on the Genetic Etiology, Radiation Exposure Damage, and Future Research Strategies.Journal of cardiovascular development and disease · 2022Review
- Risk of cancer in young and older patients with congenital heart disease and the excess risk of cancer by syndromes, organ transplantation and cardiac surgery: Swedish health registry study (1930-2017).The Lancet regional health. Europe · 2022Article
- The relationship between congenital heart disease and cancer in Swedish children: A population-based cohort study.PLoS medicine · 2022Article
- Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: the COCCINELLE study cohort profile.BMJ open · 2021Article
- Article
- Cancer Risk by Attained Age among Children with Birth Defects in Arkansas.Cancer epidemiology · 2020Article
- Flexible Modeling of the Association Between Cumulative Exposure to Low-Dose Ionizing Radiation From Cardiac Procedures and Risk of Cancer in Adults With Congenital Heart Disease.American journal of epidemiology · 2019Article
- Risk of Cancer Among Children and Young Adults With Congenital Heart Disease Compared With Healthy Controls.JAMA network open · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between congenital heart disease (CHD) and malignancies has not been determined. This study aimed to explore the association of CHD with malignancies and examine the risk factors for the development of cancer after a diagnosis of CHD. PATIENTS AND
methodsThis nationwide, population-based cohort study on cancer risk evaluated 31,961 patients with newly diagnosed CHD using the Taiwan National Health Insurance Research Database (NHIRD) between 1998 and 2006. The standardized incidence ratios (SIRs) for all and specific cancer types were analyzed, while the Cox proportional hazard model was used to evaluate risk factors of cancer occurrence.
resultsAmong patients with newly diagnosed CHD regardless of ages, 187 (0.6%) subsequently developed cancers after a diagnosis of CHD. Patients with CHD had increased risk of cancer (SIR, 1.45; 95% CI, 1.25-1.67), as well as significantly elevated risks of hematologic (SIR, 4.04; 95% CI, 2.76-5.70), central nervous system (CNS) (SIR, 3.51; 95% CI, 1.92-5.89), and head and neck (SIR, 1.81; 95% CI, 1.03-2.94) malignancies. Age (HR, 1.06; 95% CI, 1.05-1.06) and co-morbid chronic liver disease (HR, 1.91; 95% CI, 1.27-2.87) were independent risk factors for cancer occurrence among CHD patients.
conclusionPatients with CHD have significantly increased cancer risk, particularly hematologic, CNS, and head and neck malignancies. Physicians who care for patients with CHD should be aware of their predisposition to malignancy after the diagnosis of CHD. Further studies are warranted to clarify the association between CHD and malignancies.
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