ArticlePloS one2015
Di-(2-ethylhexyl) phthalate metabolites in urine show age-related changes and associations with adiposity and parameters of insulin sensitivity in childhood.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
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The trial behind it
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Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Association of exposure to phthalates with cardiometabolic risk factors in children and adolescents: a systematic review and meta-analysis.Environmental science and pollution research international · 2019Pooled it
- Phthalate exposure and metabolic effects: a systematic review of the human epidemiological evidence.Environment international · 2019Pooled it
- Phthalate exposure and female reproductive and developmental outcomes: a systematic review of the human epidemiological evidence.Environment international · 2019Pooled it
- Systematic review and meta-analysis on the association between phthalates exposure and insulin resistance.Environmental science and pollution research international · 2019Pooled it
- Hair-Based Biomonitoring of Phthalate Metabolites and Triclosan in Childhood: Links with Metabolic and Endocrine Disorders.Journal of xenobiotics · 2026Article
- Neonatal exposure to di-(2-ethylhexyl) phthalate (DEHP) through breastfeeding leads to dysfunction endocrine-metabolic outcomes in male rats at adulthood.Frontiers in endocrinology · 2026Article
- Review
- Insights into pubertal development: a narrative review on the role of epigenetics.Journal of endocrinological investigation · 2025Review
- Endocrine Disruptors in Child Obesity and Related Disorders: Early Critical Windows of Exposure.Current nutrition reports · 2025Review
- Study of Endocrine-Disrupting Chemicals in Infant Formulas and Baby Bottles: Data from the European LIFE-MILCH PROJECT.Molecules (Basel, Switzerland) · 2024Article
- Associations of early life phthalate exposures with adolescent lipid levels and insulin resistance: The HOME Study.International journal of hygiene and environmental health · 2023Article
- Article
- The possible thyroid disruptive effect of di-(2-ethyl hexyl) phthalate and the potential protective role of selenium and curcumin nanoparticles: a toxicological and histological study.Toxicology research · 2022Article
- Role of epidemiology in risk assessment: a case study of five ortho-phthalates.Environmental health : a global access science source · 2021Article
- Urinary di(2-ethylhexyl)phthalate metabolite ratios in obese children of South Korea.Environmental science and pollution research international · 2021Article
- Microplastics, environment and child health.Italian journal of pediatrics · 2021Article
- Intrauterine exposure to low-dose DBP in the mice induces obesity in offspring via suppression of UCP1 mediated ER stress.Scientific reports · 2020Article
- The endocrine disruptor DEHP and the ECS: analysis of a possible crosstalk.Endocrine connections · 2020Article
- Serum beta-carotene modifies the association between phthalate mixtures and insulin resistance: The National Health and Nutrition Examination Survey 2003-2006.Environmental research · 2019Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPhthalates might be implicated with obesity and insulin sensitivity. We evaluated the levels of primary and secondary metabolites of Di-(2-ethylhexyl) phthalate (DEHP) in urine in obese and normal-weight subjects both before and during puberty, and investigated their relationships with auxological parameters and indexes of insulin sensitivity. DESIGN AND
methodsDEHP metabolites (MEHP, 6-OH-MEHP, 5-oxo-MEHP, 5-OH-MEHP, and 5-CX-MEHP), were measured in urine by RP-HPLC-ESI-MS. Traditional statistical analysis and a data mining analysis using the Auto-CM analysis were able to offer an insight into the complex biological connections between the studied variables.
resultsThe data showed changes in DEHP metabolites in urine related with obesity, puberty, and presence of insulin resistance. Changes in urine metabolites were related with age, height and weight, waist circumference and waist to height ratio, thus to fat distribution. In addition, clear relationships in both obese and normal-weight subjects were detected among MEHP, its products of oxidation and measurements of insulin sensitivity.
conclusionIt remains to be elucidated whether exposure to phthalates per se is actually the risk factor or if the ability of the body to metabolize phthalates is actually the key point. Further studies that span from conception to elderly subjects besides further understanding of DEHP metabolism are warranted to clarify these aspects.
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