ArticleNature neuroscience2015
A subcortical inhibitory signal for behavioral arrest in the thalamus.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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Who cites it
43 citing papers in PubMed, 83 citations in OpenAlex.
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- Early microglial response to amyloid plaques drives sleep loss in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice.Nature communications · 2025Article
- Article
- A cortico-subcortical loop for motor control via the pontine reticular formation.Cell reports · 2025Article
- Convergent direct and indirect cortical streams shape avoidance decisions in mice via the midline thalamus.Nature communications · 2024Article
- Attenuating midline thalamus bursting to mitigate absence epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Brain Mechanisms Underlying Panic Attack and Panic Disorder.Neuroscience bulletin · 2024Review
- The rostral intralaminar nuclear complex of the thalamus supports striatally mediated action reinforcement.eLife · 2023Article
- Micropopulation mapping of the mouse parafascicular nucleus connections reveals diverse input-output motifs.Frontiers in neuroanatomy · 2023Article
- Dynamic control of visually guided locomotion through corticosubthalamic projections.Cell reports · 2022Article
- Identification of amacrine neurons with a glycinergic and GABAergic phenotype in the mouse retina.Medical research archives · 2022Article
- Neurotransmitter content heterogeneity within an interneuron class shapes inhibitory transmission at a central synapse.Frontiers in cellular neuroscience · 2022Article
- Probing the Functional and Structural Connectivity Underlying EEG Traveling Waves.Brain topography · 2022Article
- Cortical low-frequency power correlates with behavioral impairment in animal model of focal limbic seizures.Epilepsia · 2021Article
- The amygdala modulates prepulse inhibition of the auditory startle reflex through excitatory inputs to the caudal pontine reticular nucleus.BMC biology · 2021Article
- Cannabidiol has a unique effect on global brain activity: a pharmacological, functional MRI study in awake mice.Journal of translational medicine · 2021Article
- Behavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HTScientific reports · 2021Article
- Rostral Intralaminar Thalamus Engagement in Cognition and Behavior.Frontiers in behavioral neuroscience · 2021Review
- Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures.Brain : a journal of neurology · 2020Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 4 countries.
Funding
Abstract
Organization of behavior requires rapid coordination of brainstem and forebrain activity. The exact mechanisms of effective communication between these regions are presently unclear. The intralaminar thalamic nuclei (IL) probably serves as a central hub in this circuit by connecting the critical brainstem and forebrain areas. We found that GABAergic and glycinergic fibers ascending from the pontine reticular formation (PRF) of the brainstem evoked fast and reliable inhibition in the IL via large, multisynaptic terminals. This inhibition was fine-tuned through heterogeneous GABAergic and glycinergic receptor ratios expressed at individual synapses. Optogenetic activation of PRF axons in the IL of freely moving mice led to behavioral arrest and transient interruption of awake cortical activity. An afferent system with comparable morphological features was also found in the human IL. These data reveal an evolutionarily conserved ascending system that gates forebrain activity through fast and powerful synaptic inhibition of the IL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.