SynthesisPloS one2015
Establishing the natural history and growth rate of ameloblastoma with implications for management: systematic review and meta-analysis.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mandibular reconstruction with custom-made extended total temporomandibular joint prosthesis after resection of ameloblastoma:A systematic review.Oral and maxillofacial surgery · 2025Pooled it
- Prevalence and Epidemiological Profile of Ameloblastoma in India: A Systematic Review and Meta-Analyses.Asian Pacific journal of cancer prevention : APJCP · 2022Pooled it
- Beyond the Midline: An Unusual Presentation of Acanthomatous Ameloblastoma in the Anterior Maxilla.Cureus · 2026Article
- Targetable alterations and personalized treatment in ameloblastoma: results from a prospective observational precision oncology study.NPJ precision oncology · 2026Article
- Gingival salivary gland choristoma in a pediatric patient: periodontal reconstruction of a rare oral heterotopia with 4-year follow-up.BMC oral health · 2026Article
- Human Amniotic Mesenchymal Stromal Cells Promote Bone Regeneration via Regulating Ameloblastoma-Derived-Bone Marrow Mesenchymal Cells Crosstalk and Autophagy in Ameloblastoma Microenvironment.Tissue engineering and regenerative medicine · 2026Article
- Race is a Contributing Factor to Clinico-Pathological Characteristics of Ameloblastoma at a Multi-Network Academic Hospital System.Journal of racial and ethnic health disparities · 2026Article
- Comparison of Recurrence Rates of Odontogenic Keratocyst and Ameloblastoma following surgical excision and peripheral ostectomy in the Maxilla.Maxillofacial plastic and reconstructive surgery · 2025Article
- Radiologic Specific Growth Rate of Ameloblastomas: A Clinicopathological Correlation.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2025Article
- Unraveling the Mysteries of Ameloblastoma in African Population: A Comprehensive Analysis of 371 Cases from Clinical, Radiological, and Histopathological Perspectives.Head and neck pathology · 2025Article
- Multidisciplinary Approach to Mandibular Ameloblastoma: A Case Report on Surgical and Prosthetic Management.The American journal of case reports · 2024Article
- An unusual presentation of peripheral ameloblastoma in the maxilla.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2024Article
- Growth rate per year of a soft tissue recurrent ameloblastoma.Clinical case reports · 2024Article
- Ameloblastoma of the Mandible in a 16-Year-Old Female-Case Report.Medicina (Kaunas, Lithuania) · 2023Article
- Role of HIF-1α in Ameloblastoma: A Systematic Review.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- The radiologic progression of ameloblastomas.SA journal of radiology · 2023Article
- Hybrid Ameloblastoma Arising from a Treated Odontogenic Keratocyst of the Mandible: A Case Report With Literature Review.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Review
- Intercellular signaling between ameloblastoma and osteoblasts.Biochemistry and biophysics reports · 2022Article
- Identification of BRAF V600E mutation in odontogenic tumors by high-performance MALDI-TOF analysis.International journal of oral science · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmeloblastoma is the second most common odontogenic tumor, known to be slow-growing, persistent, and locally aggressive. Recent data suggests that ameloblastoma is best treated with wide resection and adequate margins. Following primary excision, bony reconstruction is often necessary for a functional and aesthetically satisfactory outcome, making early diagnosis paramount. Despite earlier diagnosis potentially limiting the extent of resection and reconstruction, an understanding of the growth rate and natural history of ameloblastoma has been notably lacking from the literature.
methodA systematic review of the literature was conducted by reviewing relevant articles from PubMed and Web of Science databases. Each article's level of evidence was formally appraised according to the Centre of Evidence Based Medicine (CEBM), with data from each utilized in a meta-analysis of growth rates for ameloblastoma.
resultsLiterature regarding the natural history of ameloblastoma is limited since the tumor is immediately acted upon at its initial detection, unless the patient voluntarily refuses a surgical intervention. From the limited data, it is derived that the highest estimated growth rate is associated with solid, multicystic type and the lowest rate with peripheral ameloblastomas. After meta-analysis, the calculated mean specific grow rate is 87.84% per year.
conclusionThe growth rate of ameloblastoma has been demonstrated, offering prognostic and management information, particularly in cases where a delay in management is envisaged.
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