ArticlePloS one2015
A network biology approach to denitrification in Pseudomonas aeruginosa.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 98 citations in OpenAlex.
- Versatile microbial community responsible for nitrate turnover in a carbonate aquifer in southwest Germany.FEMS microbiology ecology · 2026Article
- Assessment and functional genomic investigation of methane and nitrogen metabolizing pathways in Pseudomonas aeruginosa strain AAK/M5.World journal of microbiology & biotechnology · 2026Article
- Plasticity in a bacterial global regulatory switch that drives a shift in antibiotic resistance and virulence.FEMS microbes · 2026Article
- Metabolic potential of newly isolated bacterial species from the deep subsurface of the Iberian Pyrite Belt.Frontiers in microbiology · 2026Article
- FleQ-Dependent regulation of the ribonucleotide reductase repressor NrdR in Pseudomonas aeruginosa during biofilm growth and infection.Scientific reports · 2025Article
- Attenuated Strains of Pseudomonas aeruginosa: A Promising Cell Factory for Rhamnolipid Production.Microbial biotechnology · 2025Review
- Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylases.bioRxiv : the preprint server for biology · 2025Article
- Nitrogen Use Efficiency in Agriculture: Integrating Biotechnology, Microbiology, and Novel Delivery Systems for Sustainable Agriculture.Plants (Basel, Switzerland) · 2025Review
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- Subsoiling-Induced Shifts in Nitrogen Dynamics and Microbial Community Structure in Semi-Arid Rainfed Maize Agroecosystems.Microorganisms · 2025Article
- The histidine kinase NahK regulates denitrification and nitric oxide accumulation through RsmA inJournal of bacteriology · 2025Article
- Malonate is relevant to the lung environment and induces genome-wide stress responses in Pseudomonas aeruginosa.Research square · 2024Article
- Ecological Trait-Based Digital Categorization of Microbial Genomes for Denitrification Potential.Microorganisms · 2024Article
- Biosynthetic potential of the sediment microbial subcommunities of an unexplored karst ecosystem and its ecological implications.MicrobiologyOpen · 2024Article
- Microbial and physicochemical water quality changes within distribution and premise plumbing systems during a chlorine conversion.PLOS water · 2024Article
- Enzymatic fermentation of rapeseed cake significantly improved the soil environment of tea rhizosphere.BMC microbiology · 2023Article
- Article
- Dynamics of bacterial and archaeal communities during horse bedding and green waste composting.PeerJ · 2023Article
- Visualization of mRNA Expression in Pseudomonas aeruginosa Aggregates Reveals Spatial Patterns of Fermentative and Denitrifying Metabolism.Applied and environmental microbiology · 2022Article
- Extracellular production of azurin from Pseudomonas aeruginosa in the presence of Triton X-100 or Tween 80.Bioprocess and biosystems engineering · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas aeruginosa is a metabolically flexible member of the Gammaproteobacteria. Under anaerobic conditions and the presence of nitrate, P. aeruginosa can perform (complete) denitrification, a respiratory process of dissimilatory nitrate reduction to nitrogen gas via nitrite (NO2), nitric oxide (NO) and nitrous oxide (N2O). This study focuses on understanding the influence of environmental conditions on bacterial denitrification performance, using a mathematical model of a metabolic network in P. aeruginosa. To our knowledge, this is the first mathematical model of denitrification for this bacterium. Analysis of the long-term behavior of the network under changing concentration levels of oxygen (O2), nitrate (NO3), and phosphate (PO4) suggests that PO4 concentration strongly affects denitrification performance. The model provides three predictions on denitrification activity of P. aeruginosa under various environmental conditions, and these predictions are either experimentally validated or supported by pertinent biological literature. One motivation for this study is to capture the effect of PO4 on a denitrification metabolic network of P. aeruginosa in order to shed light on mechanisms for greenhouse gas N2O accumulation during seasonal oxygen depletion in aquatic environments such as Lake Erie (Laurentian Great Lakes, USA). Simulating the microbial production of greenhouse gases in anaerobic aquatic systems such as Lake Erie allows a deeper understanding of the contributing environmental effects that will inform studies on, and remediation strategies for, other hypoxic sites worldwide.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.