ArticlePloS one2015
Air-adapted Methanosarcina acetivorans shows high methane production and develops resistance against oxygen stress.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Nitrate reduction salvage pathway inFrontiers in microbiology · 2026Article
- Cultivation and genomic characterization of novel methanogens from arid desert biocrust.ISME communications · 2026Article
- Structure of the Methanosarcina mazei Mtr complex bound to the oxygen-stress responsive small protein MtrI.Nature communications · 2025Article
- Overexpression of 2-mercaptoethanesulfonate biosynthesis genesJournal of bacteriology · 2025Article
- Aldehyde dehydrogenase activity is induced by oxygen exposure in the anaerobic archaeon Methanosarcina acetivorans.World journal of microbiology & biotechnology · 2025Article
- Cell surface differences within the genusJournal of bacteriology · 2025Review
- Micro-aeration for improving anaerobic treatment and biogas production from organic pollutants.Applied microbiology and biotechnology · 2025Review
- Duration of OEnvironmental science & technology · 2025Article
- Metabolic interactions underpinning high methane fluxes across terrestrial freshwater wetlands.Nature communications · 2025Article
- Coastal methane emissions driven by aerotolerant methanogens using seaweed and seagrass metabolites.Nature geoscience · 2025Article
- Prospects of phosphate solubilizing microorganisms in sustainable agriculture.World journal of microbiology & biotechnology · 2024Review
- Catalytic Activity of the Archetype from Group 4 of the FTR-like Ferredoxin:Thioredoxin Reductase Family Is Regulated by UniqueBiochemistry · 2024Article
- Effect of micro-aeration on syntrophic and methanogenic activity in anaerobic sludge.Applied microbiology and biotechnology · 2024Article
- Overview of Diverse Methyl/Alkyl-Coenzyme M Reductases and Considerations for Their Potential Heterologous Expression.Frontiers in microbiology · 2022Review
- Insights into the biotechnology potential ofFrontiers in microbiology · 2022Review
- Anaerobic Production of Isoprene by EngineeredApplied and environmental microbiology · 2021Article
- Diverse methanogens, bacteria and tannase genes in the feces of the endangered volcano rabbit (PeerJ · 2021Article
- Review
- The potential for polyphosphate metabolism in Archaea and anaerobic polyphosphate formation in Methanosarcina mazei.Scientific reports · 2019Article
- Bioinformatics Analysis of Metabolism Pathways of Archaeal Energy Reserves.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methanosarcina acetivorans, considered a strict anaerobic archaeon, was cultured in the presence of 0.4-1% O2 (atmospheric) for at least 6 months to generate air-adapted cells; further, the biochemical mechanisms developed to deal with O2 were characterized. Methane production and protein content, as indicators of cell growth, did not change in air-adapted cells respect to cells cultured under anoxia (control cells). In contrast, growth and methane production significantly decreased in control cells exposed for the first time to O2. Production of reactive oxygen species was 50 times lower in air-adapted cells versus control cells, suggesting enhanced anti-oxidant mechanisms that attenuated the O2 toxicity. In this regard, (i) the transcripts and activities of superoxide dismutase, catalase and peroxidase significantly increased; and (ii) the thiol-molecules (cysteine + coenzyme M-SH + sulfide) and polyphosphate contents were respectively 2 and 5 times higher in air-adapted cells versus anaerobic-control cells. Long-term cultures (18 days) of air-adapted cells exposed to 2% O2 exhibited the ability to form biofilms. These data indicate that M. acetivorans develops multiple mechanisms to contend with O2 and the associated oxidative stress, as also suggested by genome analyses for some methanogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.