Evidence map›Paper›PMID 25706090›Full record

Trial reportCognitive behaviour therapy2015

Exercise Augmentation of Exposure Therapy for PTSD: Rationale and Pilot Efficacy Data.

Mark B Powers, Johnna L Medina, Stephanie Burns, Brooke Y Kauffman, Marie Monfils, Gordon J G Asmundson, Allison Diamond, Christa McIntyre, Jasper A J Smits

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cognitive behaviour therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01998100 (Maximizing Treatment Outcome in Post-Traumatic Stress Disorder), which is not on this map. Cited by 77 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 6 pooled it
5.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01998100 phase3completednot on this map

Maximizing Treatment Outcome in Post-Traumatic Stress Disorder (PTSD)

TypeinterventionalSponsorUniversity of Texas at AustinRan2010 to 2013Enrolled28ConditionsPost-Traumatic Stress DisorderArmsProlonged Exposure, Exercise
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 6 syntheses or guidelines pooled it, 194 citations in OpenAlex.

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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mark B Powersa Department of Psychology, Institute for Mental Health Research , The University of Texas at Austin , Austin , TX , USA.
Johnna L Medina
Stephanie Burns
Brooke Y Kauffman
Marie Monfils
Gordon J G Asmundson
Allison Diamond
Christa McIntyre
Jasper A J Smits
The University of Texas at Austin · USThe University of Texas at Dallas · USUniversity of Regina · CA

Funding

Exercise Intervention for SmokingR01DA027533 · NIDA · SOUTHERN METHODIST UNIVERSITY · PI ROSENFIELD, DAVID I, SMITS, JASPER · 2009 to 2012
$2.3M
Fear memory attenuation: testing reconsolidation-extinction boundariesR01MH091147 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI MONFILS, MARIE H. · 2011 to 2015
$1.9M
Integrated PTSD and Smoking TreatmentK01DA035930 · NIDA · UNIVERSITY OF TEXAS AT AUSTIN · PI POWERS, MARK B · 2013 to 2017
$857k
Mechanisms of Extinction of Conditioned Fear by Vagus Nerve StimulationR15MH099655 · NIMH · UNIVERSITY OF TEXAS DALLAS · PI MCINTYRE, CHRISTA · 2013 to 2013
$430k
Biobehavioral Mechanisms Underlying Yoga's Effects on Nicotine WithdrawalF31DA036919 · NIDA · UNIVERSITY OF TEXAS AT AUSTIN · PI MEDINA, JOHNNA · 2014 to 2015
$76k
NIDA NIH HHS F31 DA036919NIDA NIH HHS K01 DA035930NIDA NIH HHS R01 DA027533NIMH NIH HHS R01 MH091147NIMH NIH HHS R15 MH099655
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) is associated with synaptic plasticity, which is crucial for long-term learning and memory. Some studies suggest that people suffering from anxiety disorders show reduced BDNF relative to healthy controls. Lower BDNF is associated with impaired learning, cognitive deficits, and poor exposure-based treatment outcomes. A series of studies with rats showed that exercise elevates BDNF and enhances fear extinction. However, this strategy has not been tested in humans. In this pilot study, we randomized participants (N = 9, 8 females, M(Age) = 34) with posttraumatic stress disorder (PTSD) to (a) prolonged exposure alone (PE) or (b) prolonged exposure+exercise (PE+E). Participants randomized to the PE+E condition completed a 30-minute bout of moderate-intensity treadmill exercise (70% of age-predicted HR(max)) prior to each PE session. Consistent with prediction, the PE+E group showed a greater improvement in PTSD symptoms (d = 2.65) and elevated BDNF (d = 1.08) relative to the PE only condition. This pilot study provides initial support for further investigation into exercise augmented exposure therapy.

Indexed as

AdultBrain-Derived Neurotrophic FactorCombined Modality TherapyExerciseExercise TherapyFemaleHumansImplosive TherapyMalePilot ProjectsStress Disorders, Post-TraumaticYoung AdultBDNF protein, humanBrain-Derived Neurotrophic Factoranxiety disordersaugmentationBDNFCBTexerciseexposure therapypilot data

Identifiers

PMID25706090
PMCPMC4464974
OpenAlexW1987008872

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.