Evidence map›Paper›PMID 25705966›Full record

ReviewMicrocirculation (New York, N.Y. : 1994)2015

Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture.

Andy Y Shih, Charlotta Rühlmann, Pablo Blinder, Anna Devor, Patrick J Drew, Beth Friedman, Per M Knutsen, Patrick D Lyden, Celine Mateo, Lisa Mellander and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Microcirculation (New York, N.Y. : 1994), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Article
  2. Microvascular architecture and physiological fluctuations constrain the control of cerebral microcirculation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Pericyte Electrical Signalling and Brain Haemodynamics.Basic & clinical pharmacology & toxicology · 2025
    Review
  9. Article
  10. Pulsatile flow in a thin-walled viscoelastic tube.Journal of fluid mechanics · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Andy Y Shih *Department of Neurosciences, Medical University of South Carolina, Charleston, SC.
Charlotta Rühlmann *Department of Physics, University of California at San Diego, La Jolla, CA.
Pablo BlinderDepartment of Neurobiology, Tel Aviv University, Tel Aviv, Israel.
Anna DevorDepartment of Neurosciences, University of California School of Medicine, La Jolla, CA.
Patrick J DrewDepartment of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA.
Beth FriedmanDepartment of Pharmacology, University of California School of Medicine, La Jolla, CA.
Per M KnutsenDepartment of Physics, University of California at San Diego, La Jolla, CA.
Patrick D LydenDepartment of Neurology, Cedars-Sinai Hospital, Los Angeles, CA.
Celine MateoDepartment of Physics, University of California at San Diego, La Jolla, CA.
Lisa MellanderDepartment of Physics, University of California at San Diego, La Jolla, CA.
Nozomi NishimuraDepartment of Biomedical Engineering, Cornell University, Ithaca, NY.
Chris B SchafferDepartment of Biomedical Engineering, Cornell University, Ithaca, NY.
Philbert S TsaiDepartment of Physics, University of California at San Diego, La Jolla, CA.
David KleinfeldDepartment of Physics, University of California at San Diego, La Jolla, CA.

Funding

Spatiotemporal Brain Imaging: Microscopic &System LevelR01EB000790 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M · 2002 to 2015
$15.3M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
Manipulating Neural Tissue With Ultra-Short Laser PulsesR01EB003832 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KAUFHOLD, JOHN, KLEINFELD, DAVID · 2005 to 2014
$8.2M
Neuronal, glial and BOLD fMRI signals: From BOLD to 2-photon microscopyR01NS057198 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEVOR, ANNA · 2009 to 2017
$2.6M
CNiFERs Cell-based Neurotransmitter Fluorescent Engineered ReportersR01DA029706 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2010 to 2014
$2.3M
Defining the Logic of Neurovascular Signaling in the BrainDP1NS082097 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2012 to 2014
$2.3M
Defining the Logic of Neurovascular Signaling in the BrainDP1OD006831 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2010 to 2011
$1.5M
Neuronal Signaling, Network Topology, and Blood Flow Dynamics in CortexR01MH085499 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2008 to 2011
$1.2M
DEEP MULTI-PHOTON IMAGING OF BRAIN STRUCTURE &FUNCTIONR01NS041096 · NINDS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI KLEINFELD, DAVID · 2000 to 2002
$1.0M
Femtosecond Light to Manipulate Neurons and VasculatureR21RR021907 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2005 to 2007
$554k
Enhanced Detection of Cerebral Microinfarcts in Dementia Using MRIR21NS085402 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SHIH, ANDY Y · 2013 to 2014
$409k
Multi-scale mapping of 3D spatial-temporal cortical hemodynamics at the level of R21NS059832 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2007 to 2008
$338k
NCATS NIH HHS UL1 TR000062NCATS NIH HHS UL1TR000062NCRR NIH HHS R21 RR021907NCRR NIH HHS RR021907NIBIB NIH HHS EB003832NIBIB NIH HHS R01 EB000790NIBIB NIH HHS R01 EB003832NIDA NIH HHS R01 DA029706NIGMS NIH HHS P20GM12345NIH HHS DP1 OD006831NIH HHS OD006831NIMH NIH HHS MH72570NIMH NIH HHS R01 MH085499NIMH NIH HHS R21 MH072570NINDS NIH HHS DP1 NS082097NINDS NIH HHS NS059832NINDS NIH HHS NS082097NINDS NIH HHS NS085402NINDS NIH HHS R01 NS041096NINDS NIH HHS R01 NS057198NINDS NIH HHS R21 NS059832NINDS NIH HHS R21 NS085402
6 · The paper itself

Abstract

We review the organizational principles of the cortical vasculature and the underlying patterns of blood flow under normal conditions and in response to occlusion of single vessels. The cortex is sourced by a two-dimensional network of pial arterioles that feeds a three-dimensional network of subsurface microvessels in close proximity to neurons and glia. Blood flow within the surface and subsurface networks is largely insensitive to occlusion of a single vessel within either network. However, the penetrating arterioles that connect the pial network to the subsurface network are bottlenecks to flow; occlusion of even a single penetrating arteriole results in the death of a 500 μm diameter cylinder of cortical tissue despite the potential for collateral flow through microvessels. This pattern of flow is consistent with that calculated from a full reconstruction of the angioarchitecture. Conceptually, collateral flow is insufficient to compensate for the occlusion of a penetrating arteriole because penetrating venules act as shunts of blood that flows through collaterals. Future directions that stem from the analysis of the angioarchitecture concern cellular-level issues, in particular the regulation of blood flow within the subsurface microvascular network, and system-level issues, in particular the role of penetrating arteriole occlusions in human cognitive impairment.

Indexed as

Cerebrovascular CirculationMicrocirculationAnimalsArteriolesCerebral CortexHumansNeurogliaNeuronsimagingmicrovesselspenetrating vesselspial vesselsrodent

Identifiers

PMID25705966
PMCPMC4393797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.