SynthesisPloS one2015
Association between glaucoma and obstructive sleep apnea syndrome: a meta-analysis and systematic review.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Obstructive sleep apnoea and glaucoma: a systematic review and meta-analysis.Eye (London, England) · 2023Pooled it
- Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies.Eye (London, England) · 2022Pooled it
- Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?Investigative ophthalmology & visual science · 2022Pooled it
- Sleep apnea and eye diseases: evidence of association and potential pathogenic mechanisms.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Pooled it
- Association between restless legs syndrome and hypertension: a meta-analysis of nine population-based studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Pooled it
- Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome: A meta-analysis.Medicine · 2016Pooled it
- Obstructive sleep apnea as a risk factor for primary open angle glaucoma and ocular hypertension in a monocentric pilot study.Respiratory research · 2020Trial
- The Pathophysiological Association Between Obstructive Sleep Apnea and Glaucoma: A Current Update.Journal of clinical medicine · 2026Review
- Prevalence of floppy eyelid syndrome and keratoconus in Egyptian patients with obstructive sleep apnea.International ophthalmology · 2026Article
- Rating Scales for Obstructive Sleep Apnea Syndrome: The Importance of a Comprehensive Assessment.Cureus · 2026Review
- Visual impairment, age-related eye disease, and sleep dysfunction in older adults.Eye (London, England) · 2025Article
- Vascular density changes in retina and optic nerve in obstructive sleep apnea syndrome cases.Sleep & breathing = Schlaf & Atmung · 2025Article
- Benefit of continuous positive airway pressure on optic nerve damage in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2025Article
- Association between obstructive sleep apnea and glaucoma.Korean journal of family medicine · 2025Article
- Obesity, body fat distribution and eye diseases.Eating and weight disorders : EWD · 2024Review
- Intraocular Pressure Variations in Postural Changes: Comparison between Obese and Non-Obese Controls.Journal of clinical medicine · 2023Article
- Primary open-angle glaucoma in patients with obstructive sleep apnoea in a Colombian population: a cross-sectional study.BMJ open · 2023Article
- Retinal and Choroidal Effects of Continuous Positive Airway Pressure as Treatment for Sleep Apnea: Results at 12 Months.International journal of environmental research and public health · 2022Article
- Optical coherence tomography angiography and Humphrey visual field in patients with obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Observational
- Multimorbidity and overall comorbidity of sleep apnoea: a Finnish nationwide study.ERJ open research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObstructive sleep apnea syndrome (OSAS) is a common disease that increases the risk of diabetes, heart disease, and stroke. However, studies of an association between OSAS and glaucoma neuropathy have reported controversial findings.
objectiveThe main purpose of this study was to evaluate whether a significant association exists between OSAS and glaucoma by performing a meta-analysis of previous studies.
methodsA comprehensive literature search using the PubMed and Embase databases was performed to identify cross-sectional, case-control, and cohort studies related to the topic. We estimated a pooled odds ratio (OR) for the association between OSAS and glaucoma, by a fixed- or random-effects model.
resultsIn total, 16 studies with 2,278,832 participants met the inclusion criteria: one retrospective cohort study reported an adjusted hazard ratio of glaucoma of 1.67 (95% CI = 1.30-2.17). Using a fixed-effects model, the pooled OR of six case-control studies was 1.96 (95% CI = 1.37 2.80). A significant association was also identified in a meta-analysis of nine cross-sectional studies using a random-effects model, which showed a pooled OR of 1.41 (95% CI = 1.11 1.79). However, the reported pooled estimates for case control studies and cross-sectional studies were based on unadjusted ORs.
conclusionsOur results suggest that OSAS is associated with the prevalence of glaucoma. However, this result was based only on unadjusted estimates. Prospective cohort studies designed to take into consideration potential confounders, or examination of data from interventional trials to determine whether a reduction in OSAS status is associated with a reduced incidence of glaucoma, are needed to clarify whether OSAS is an independent risk factor for glaucoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.