ArticlePloS one2015
Predomination and new genotypes of Enterocytozoon bieneusi in captive nonhuman primates in zoos in China: high genetic diversity and zoonotic significance.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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79 citing papers in PubMed.
- Distribution and genotypes of Enterocytozoon bieneusi in raccoon dogs in Korea.Parasites, hosts and diseases · 2025Article
- Identification of zoonotic pathogens in zoo animals in the Republic of Korea.International journal for parasitology. Parasites and wildlife · 2025Article
- Molecular Detection and Genotyping ofInternational journal of molecular sciences · 2025Article
- Molecular evidence of host range expansion ofOne health (Amsterdam, Netherlands) · 2025Article
- Distribution and genotypic analysis of Enterocytozoon bieneusi from cats in Korea.Parasites, hosts and diseases · 2025Article
- Investigation of Cryptosporidium spp. and Enterocytozoon bieneusi in free-ranged livestock on the southeastern Qinghai-Xizang Plateau, China.BMC infectious diseases · 2025Article
- Prevalence and genotypic identification of Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi in farmed ostriches (Struthio camelus) by the Yellow River in Zhengzhou city, central China.BMC veterinary research · 2025Article
- Identification of two new genetic loci for high-resolution genotyping of Enterocytozoon bieneusi.Parasite (Paris, France) · 2025Article
- Distribution of human-pathogenicFrontiers in microbiology · 2025Article
- Gastrointestinal protozoa in pet cats from Anhui province: prevalence and molecular characterization.Frontiers in cellular and infection microbiology · 2025Article
- Genotypic analysis of zoonotic Enterocytozoon bieneusi in wild deer in Korea.Parasites, hosts and diseases · 2024Article
- Detection ofAnimals : an open access journal from MDPI · 2024Article
- Epidemiology and Molecular Characterization of Zoonotic Gastrointestinal Protozoal Infection in Zoo Animals in China.Animals : an open access journal from MDPI · 2024Article
- Molecular characterization of Enterocytozoon bieneusi genotypes in wild Altai marmot (Marmota baibacina) in Xinjiang, China: host specificity and adaptation.Parasitology research · 2023Article
- Microscopic and Molecular Investigation of Intestinal Microsporidia in HIV + /AIDS and Cancer Patients Undergoing Chemotherapy in Mazandaran Province, North of Iran.Acta parasitologica · 2023Article
- Occurrence and Molecular Characteristics of Microsporidia in Captive Red Pandas (Animals : an open access journal from MDPI · 2023Article
- High genotype diversity and zoonotic potential of Enterocytozoon bieneusi in yaks (Bos grunniens) from Ganzi Tibetan Autonomous Prefecture, Sichuan Province.Parasite (Paris, France) · 2023Article
- Novel genotypes ofInternational journal for parasitology. Parasites and wildlife · 2022Article
- Seasonal distribution of Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi in Tibetan sheep in Qinghai, China.Parasites & vectors · 2022Article
- Prevalence and new genotypes ofInternational journal for parasitology. Parasites and wildlife · 2022Article
19 more citing papers are in PubMed but not listed here.
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12 authors.
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Abstract
To appreciate the genetic diversity and zoonotic implications of Enterocytozoon bieneusi in nonhuman primates (NHPs) in zoos, we genotyped E. bieneusi in captive NHPs in seven zoos located at six major cities in China, using ribosomal internal transcribed spacer (ITS)-based PCR and sequence analyses. A total of 496 fecal specimens from 36 NHP species under nine families were analyzed and E. bieneusi was detected in 148 (29.8%) specimens of 25 NHP species from six families, including Cercopithecidae (28.7%), Cebidae (38.0%), Aotidae (75.0%), Lemuridae (26.0%), Hylobatidae (50.0%) and Hominidae (16.2%) (P = 0.0605). The infection rates were 29.0%, 15.2%, 18.2%, 37.3%, 29.2%, 37.7% and 44.8% in Shijiazhuang Zoo, Wuhan Zoo, Taiyuan Zoo, Changsha Wild Animal Zoo, Beijing Zoo, Shanghai Zoo and Shanghai Wild Animal Park, respectively (P = 0.0146). A total of 25 ITS genotypes were found: 14 known (D, O, EbpC, EbpA, Type IV, Henan-IV, BEB6, BEB4, Peru8, PigEBITS5, EbpD, CM1, CM4 and CS-1) and 11 new (CM8 to CM18). Genotype D was the most prevalent one (40/148), followed by CM4 (20/148), CM1 (15/148), O (13/148), CM16 (13/148), EbpC (11/148). Of them, genotypes D, EbpC, CM4 and O were widely distributed in NHPs (seen in 9 to 12 species) whereas genotypes CM1 and CM16 were restricted to one to three NHP species. In phylogenetic analysis, 20 genotypes (121/148, 81.8%), excluding genotypes BEB4, BEB6, CM9, CM4 and CM18, belonged to group 1 with zoonotic potential. New genotype CM9 clustered in group 2 with BEB4 and BEB6. The remaining two genotypes CM4 and CM18 formed new cluster (group 9) in between two other genotypic clusters found in primates. The findings of high diversity in E. bieneusi genotypes and their zoonotic potentiality concluded the importance of captive NHPs as reservoir hosts for human microsporidiosis.
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