ArticleBioMed research international2015
Pan-genome analysis of human gastric pathogen H. pylori: comparative genomics and pathogenomics approaches to identify regions associated with pathogenicity and prediction of potential core therapeutic targets.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Correlation between the geographical origin of Helicobacter pylori homB-positive strains and their clinical outcomes: a systematic review and meta-analysis.BMC gastroenterology · 2021Pooled it
- Effects of periodontal therapy on eradication and recurrence of Helicobacter pylori infection after successful treatment.The Journal of international medical research · 2019Trial
- Molecular insights into pangenome localization and constructs design for Hemophilus influenza vaccine.Scientific reports · 2025Article
- Comparative genomic analysis of Helicobacter pylori isolates from gastric cancer and gastritis in China.BMC cancer · 2025Article
- TargetingMolecules (Basel, Switzerland) · 2023Article
- Recent Advances in Genomics-Based Approaches for the Development of Intracellular Bacterial Pathogen Vaccines.Pharmaceutics · 2022Review
- Novel Chimeric Vaccine Candidate Development againstInternational journal of environmental research and public health · 2022Article
- Pan-Genome Analysis of Oral Bacterial Pathogens to Predict a Potential Novel Multi-Epitopes Vaccine Candidate.International journal of environmental research and public health · 2022Article
- Computer-Aided Multi-Epitope Vaccine Design againstInternational journal of environmental research and public health · 2022Article
- Vaccinomics to Design a Multi-Epitopes Vaccine forInternational journal of environmental research and public health · 2022Article
- Immunoinformatics and Biophysics Approaches to Design a Novel Multi-Epitopes Vaccine Design againstVaccines · 2022Article
- An integrated computational framework to design a multi-epitopes vaccine against Mycobacterium tuberculosis.Scientific reports · 2021Article
- Towards A Novel Multi-Epitopes Chimeric Vaccine for Simulating Strong Immune Responses and Protection againstInternational journal of environmental research and public health · 2021Article
- Proteome-wide analysis of Coxiella burnetii for conserved T-cell epitopes with presentation across multiple host species.BMC bioinformatics · 2021Article
- Whole-Genome Sequencing and Comparative Genomics of ThreePathogens (Basel, Switzerland) · 2021Article
- Immunization with SP_1992 (DiiA) Protein ofVaccines · 2021Article
- Towards a novel peptide vaccine for Middle East respiratory syndrome coronavirus and its possible use against pandemic COVID-19.Journal of molecular liquids · 2021Article
- Helicobacter pylori treatment in the post-antibiotics era-searching for new drug targets.Applied microbiology and biotechnology · 2020Review
- Pan-genomics in the human genome era.Nature reviews. Genetics · 2020Review
- EpitoCore: Mining Conserved Epitope Vaccine Candidates in the Core Proteome of Multiple Bacteria Strains.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori is a human gastric pathogen implicated as the major cause of peptic ulcer and second leading cause of gastric cancer (~70%) around the world. Conversely, an increased resistance to antibiotics and hindrances in the development of vaccines against H. pylori are observed. Pan-genome analyses of the global representative H. pylori isolates consisting of 39 complete genomes are presented in this paper. Phylogenetic analyses have revealed close relationships among geographically diverse strains of H. pylori. The conservation among these genomes was further analyzed by pan-genome approach; the predicted conserved gene families (1,193) constitute ~77% of the average H. pylori genome and 45% of the global gene repertoire of the species. Reverse vaccinology strategies have been adopted to identify and narrow down the potential core-immunogenic candidates. Total of 28 nonhost homolog proteins were characterized as universal therapeutic targets against H. pylori based on their functional annotation and protein-protein interaction. Finally, pathogenomics and genome plasticity analysis revealed 3 highly conserved and 2 highly variable putative pathogenicity islands in all of the H. pylori genomes been analyzed.
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