Evidence map›Paper›PMID 25705263›Full record

ArticleClinical lipidology

The mutual interplay of lipid metabolism and the cells of the immune system in relation to atherosclerosis.

Godfrey S Getz, Catherine A Reardon

Abstract read
In one paragraph

Article in Clinical lipidology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
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  6. Article
  7. Article
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  9. Article
  10. Article
  11. Big Data Reveal Insights into Alopecia Areata Comorbidities.The journal of investigative dermatology. Symposium proceedings · 2018
    Article
  12. Article
  13. Healthy Adult LDL-C Bears Reverse Association with Serum IL-17A Levels.Current chemical genomics and translational medicine · 2018
    Article
  14. βInternational journal of medical sciences · 2017
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Godfrey S GetzDepartment of Pathology, University of Chicago, Box MC 1089, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.
Catherine A ReardonDepartment of Pathology, University of Chicago, Box MC 1089, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.
University of Chicago · US

Funding

NKT cells in lipoprotein Metabolism and atherosclerosisR01HL088420 · NHLBI · UNIVERSITY OF CHICAGO · PI GETZ, GODFREY SHALOM · 2008 to 2011
$1.5M
Receptors Mediating Lymphotoxin Effects on AthersclerosisR01HL086675 · NHLBI · UNIVERSITY OF CHICAGO · PI GETZ, GODFREY SHALOM · 2008 to 2011
$1.5M
Lymphotoxin/LIGHT in Lipoprotein Metabolism and AtherosclerosisR01HL085516 · NHLBI · UNIVERSITY OF CHICAGO · PI GETZ, GODFREY SHALOM · 2006 to 2009
$1.5M
NHLBI NIH HHS R01 HL085516NHLBI NIH HHS R01 HL086675NHLBI NIH HHS R01 HL088420
6 · The paper itself

Abstract

Atherosclerosis is a chronic inflammation in the arterial wall involving cells of the innate and adaptive immune system that is promoted by hyperlipidemia. In addition, the immune system can influence lipids and lipoprotein levels and cellular lipid homeostasis can influence the level and function of the immune cells. We will review the effects of manipulation of adaptive immune cells and immune cell products on lipids and lipoproteins, focusing mainly on studies performed in murine models of atherosclerosis. We also review how lipoproteins and cellular lipid levels, particularly cholesterol levels, influence the function of cells of the innate and adaptive immune systems. The overriding theme is that these interactions are driven by the need to provide the energy and membrane components for cell proliferation and migration, membrane expansion and other functions that are so important in the functioning of the immune cells.

Indexed as

adaptive immune systemcellular lipidcholesterol biosynthesiscytokineinnate immune systemlipid effluxlipid raftslipoproteinoxysterolplasma lipid

Identifiers

PMID25705263
PMCPMC4335315
OpenAlexW2103248747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.