ArticleFrontiers in zoology2015
Repeated stressors in adulthood increase the rate of biological ageing.
Article in Frontiers in zoology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Pooled it
- Tracking the Pulse of the Dunes: Seasonal Metabolic Responses of Liolaemus arambarensis to Climatic Variability.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- State-Dependent and Social Modulation of Circulating Glucocorticoids in a Nomadic Songbird, the Red Crossbill (Integrative organismal biology (Oxford, England) · 2026Article
- Repeated experimental challenges do not shorten adult telomeres in a songbird.Proceedings. Biological sciences · 2025Article
- Unpredictable warm spells in winter increase blood cortisol level but lengthen telomeres in a seasonal rodentProceedings. Biological sciences · 2025Article
- Does seasonal variation in the corticosterone response affect the nutritional ecology of a free-ranging lizard?The Journal of animal ecology · 2025Article
- Activation of the sympathetic-adrenal-medullary system increases DNA damage during the transition to captivity.Integrative organismal biology (Oxford, England) · 2025Article
- A conceptual framework for understanding stress-induced physiological and transgenerational effects on population responses to climate change.Evolution letters · 2024Article
- The response to stressors in adulthood depends on the interaction between prenatal exposure to glucocorticoids and environmental context.Scientific reports · 2023Article
- Oxidative physiology of two small and highly migratory Arctic seabirds: Arctic terns (Conservation physiology · 2023Article
- Stressors interact across generations to influence offspring telomeres and survival.Proceedings. Biological sciences · 2022Article
- Effects of stress exposure in captivity on physiology and infection in avian hosts: no evidence of increased Borrelia burgdorferi s.l. infectivity to vector ticks.Microbial ecology · 2022Article
- A meta-analysis of impacts of immune response and infection on oxidative status in vertebrates.Conservation physiology · 2022Article
- New Perspectives on Avian Models for Studies of Basic Aging Processes.Biomedicines · 2021Review
- Individual telomere dynamics and their links to life history in a viviparous lizard.Proceedings. Biological sciences · 2021Article
- Alterations in telomere length and mitochondrial DNA copy number in human lymphocytes on short-term exposure to moderate hypoxia.Toxicology reports · 2020Article
- Developmental conditions modulate DNA methylation at the glucocorticoid receptor gene with cascading effects on expression and corticosterone levels in zebra finches.Scientific reports · 2019Article
- Intergenerational effects on offspring telomere length: interactions among maternal age, stress exposure and offspring sex.Proceedings. Biological sciences · 2019Article
- Oxidative stress and mitochondrial responses to stress exposure suggest that king penguins are naturally equipped to resist stress.Scientific reports · 2019Article
- Ultralong telomeres shorten with age in nestling great tits but are static in adults and mask attrition of short telomeres.Molecular ecology resources · 2019Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals of the same age can differ substantially in the degree to which they have accumulated tissue damage, akin to bodily wear and tear, from past experiences. This accumulated tissue damage reflects the individual's biological age and may better predict physiological and behavioural performance than the individual's chronological age. However, at present it remains unclear how to reliably assess biological age in individual wild vertebrates.
methodsWe exposed hand-raised adult Eurasian blackbirds (Turdus merula) to a combination of repeated immune and disturbance stressors for over one year to determine the effects of chronic stress on potential biomarkers of biological ageing including telomere shortening, oxidative stress load, and glucocorticoid hormones. We also assessed general measures of individual condition including body mass and locomotor activity.
resultsBy the end of the experiment, stress-exposed birds showed greater decreases in telomere lengths. Stress-exposed birds also maintained higher circulating levels of oxidative damage compared with control birds. Other potential biomarkers such as concentrations of antioxidants and glucocorticoid hormone traits showed greater resilience and did not differ significantly between treatment groups.
conclusionsThe current data demonstrate that repeated exposure to experimental stressors affects the rate of biological ageing in adult Eurasian blackbirds. Both telomeres and oxidative damage were affected by repeated stress exposure and thus can serve as blood-derived biomarkers of biological ageing.
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