ArticleFrontiers in behavioral neuroscience2015
The effect of retrosplenial cortex lesions in rats on incidental and active spatial learning.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Unique Transcriptomic Cell Types of the Granular Retrosplenial Cortex Are Preserved across Mice and Rats despite Dramatic Changes in Key Marker Genes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The clock gene Per1 is necessary in the retrosplenial cortex-but not in the suprachiasmatic nucleus-for incidental learning in young and aging male mice.Neurobiology of aging · 2023Article
- Perineuronal nets affect memory and learning after synapse withdrawal.Translational psychiatry · 2022Article
- Collateral rostral thalamic projections to prelimbic, infralimbic, anterior cingulate and retrosplenial cortices in the rat brain.The European journal of neuroscience · 2022Article
- Contextual experience modifies functional connectome indices of topological strength and efficiency.Scientific reports · 2020Article
- Dysregulation of protein degradation in the hippocampus is associated with impaired spatial memory during the development of obesity.Behavioural brain research · 2020Article
- The Visual Cortex in Context.Annual review of vision science · 2019Review
- Neural correlates of sparse coding and dimensionality reduction.PLoS computational biology · 2019Review
- When is the rat retrosplenial cortex required for stimulus integration?Behavioral neuroscience · 2018Article
- Cholinergic modulation of spatial learning, memory and navigation.The European journal of neuroscience · 2018Review
- The cingulum bundle: Anatomy, function, and dysfunction.Neuroscience and biobehavioral reviews · 2018Review
- Network supporting contextual fear learning after dorsal hippocampal damage has increased dependence on retrosplenial cortex.PLoS computational biology · 2018Article
- Retrosplenial cortex and its role in spatial cognition.Brain and neuroscience advances · 2018Review
- The rat retrosplenial cortex as a link for frontal functions: A lesion analysis.Behavioural brain research · 2017Article
- Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms.Biological psychiatry · 2017Review
- Perirhinal cortex lesions that impair object recognition memory spare landmark discriminations.Behavioural brain research · 2016Article
- Thalamic pathology and memory loss in early Alzheimer's disease: moving the focus from the medial temporal lobe to Papez circuit.Brain : a journal of neurology · 2016Review
- Comparative density of CCK- and PV-GABA cells within the cortex and hippocampus.Frontiers in neuroanatomy · 2015Article
- What does spatial alternation tell us about retrosplenial cortex function?Frontiers in behavioral neuroscience · 2015Article
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Authors and funding
5 authors.
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Abstract
The study examined the importance of the retrosplenial cortex for the incidental learning of the spatial arrangement of distinctive features within a scene. In a modified Morris water-maze, rats spontaneously learnt the location of an escape platform prior to swimming to that location. For this, rats were repeatedly placed on a submerged platform in one corner of either a rectangular (Experiment 1) or square (Experiments 2, 3) pool with walls of different appearance. The rats were then released in the center of the pool for their first test trial. In Experiment 1, the correct corner and its diagonally opposite partner (also correct) were specified by the geometric properties of the pool. Rats with retrosplenial lesions took longer to first reach a correct corner, subsequently showing an attenuated preference for the correct corners. A reduced preference for the correct corner was also found in Experiment 2, when platform location was determined by the juxtaposition of highly salient visual cues (black vs. white walls). In Experiment 3, less salient visual cues (striped vs. white walls) led to a robust lesion impairment, as the retrosplenial lesioned rats showed no preference for the correct corner. When subsequently trained actively to swim to the correct corner over successive trials, retrosplenial lesions spared performance on all three discriminations. The findings not only reveal the importance of the retrosplenial cortex for processing various classes of visuospatial information but also highlight a broader role in the incidental learning of the features of a spatial array, consistent with the translation of scene information.
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