Evidence map›Paper›PMID 25705139›Full record

ArticlePediatric rheumatology online journal2015

Endothelial progenitor cell levels in juvenile idiopathic arthritis patients: effects of anti-inflammatory therapies.

Malgorzata Rusak, Urszula Radzikowska, Barbara Glowinska-Olszewska, Elzbieta Dobrenko, Janina Piotrowska-Jastrzebska, Milena Dabrowska, Anna Bodzenta-Lukaszyk, Artur Bossowski, Marcin Moniuszko

Open access · goldAbstract read
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In one paragraph

Article in Pediatric rheumatology online journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Malgorzata RusakDepartment of Hematological Diagnostics, Medical University of Bialystok, 15-274 Bialystok, Poland.
Urszula RadzikowskaDepartment of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, 15-269 Bialystok, Poland.
Barbara Glowinska-OlszewskaDepartment of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, 15-274 Białystok, Poland.
Elzbieta DobrenkoDepartment of Pediatrics and Developmental Disorders, Medical University of Bialystok, 15-274 Białystok, Poland.
Janina Piotrowska-JastrzebskaDepartment of Pediatrics and Developmental Disorders, Medical University of Bialystok, 15-274 Białystok, Poland.
Milena DabrowskaDepartment of Hematological Diagnostics, Medical University of Bialystok, 15-274 Bialystok, Poland.
Anna Bodzenta-LukaszykDepartment of Allergology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.
Artur BossowskiDepartment of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, 15-274 Białystok, Poland.
Marcin MoniuszkoDepartment of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, 15-269 Bialystok, Poland ; Department of Allergology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.
Medical University of Białystok · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundJuvenile idiopathic arthritis (JIA), similarly to other arthritides, can be associated with damage of endothelial layer of which structure and function is dependent on reparative properties of endothelial progenitor cells (EPC). To date, it remained unknown whether EPC numbers are altered in young JIA patients and whether on-going anti-inflammatory therapies could exert positive effects on these progenitor cells.

methodsWe performed a quantitative analysis of EPC numbers in 25 patients diagnosed with JIA according to International League of Associations for Rheumatism (ILAR) criteria [age 11.50 (7.50-15.00) years] in a broad context of inflammatory and cardiovascular parameters as well as different types of anti-inflammatory treatments. 11 healthy children [age 13.00 (11.00-14.00) years] were recruited as a control group.

resultsWe demonstrated that EPC numbers were similar in JIA patients and control subjects (0.02% vs. 0.05%, respectively, p = 0.37). EPC levels in JIA patients were negatively correlated with index of insulin resistance (rho = -0.458, p = 0.021), endogenous insulin (rho = -0.472, p = 0.017), triglyceride (rho = -0.438, p = 0.029) and TNF-alpha levels (rho = -0.446, p = 0.026). Notably, glucocorticoid (GC) therapy, was associated with detection of decreased EPC levels in JIA patients (p = 0.023). In contrast, methothrexate (MTX) and etanercept therapy in JIA patients did not affect EPC levels (p = 0.92 and p = 0.08, respectively).

conclusionsWe found that EPC numbers are maintained at normal levels in JIA patients and are not enhanced by disease-specific anti-inflammatory treatments.

Indexed as

AdolescentAntigens, CD34Anti-Inflammatory AgentsArthritis, JuvenileCase-Control StudiesCell CountChildCross-Sectional StudiesEndothelial Progenitor CellsEtanerceptFemaleGlucocorticoidsHumansImmunoglobulin GMaleMethotrexateAntigens, CD34Anti-Inflammatory AgentsEtanerceptGlucocorticoidsImmunoglobulin GMethotrexateReceptors, Tumor Necrosis FactorVascular Endothelial Growth Factor Receptor-2Anti-inflammatory therapiesCardiovascular risk factorsEndothelial progenitor cellsJuvenile idiopathic arthritis

Identifiers

PMID25705139
PMCPMC4336757
OpenAlexW2107747972

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.