ArticleNeuron2015
Implementation of linear sensory signaling via multiple coordinated mechanisms at central vestibular nerve synapses.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Interactions between circuit architecture and plasticity in a closed-loop cerebellar system.eLife · 2024Article
- The Nature and Origin of Synaptic Inputs to Vestibulospinal Neurons in the Larval Zebrafish.eNeuro · 2023Article
- The nature and origin of synaptic inputs to vestibulospinal neurons in the larval zebrafish.bioRxiv : the preprint server for biology · 2023Article
- Role of GluA3 AMPA Receptor Subunits in the Presynaptic and Postsynaptic Maturation of Synaptic Transmission and Plasticity of Endbulb-Bushy Cell Synapses in the Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Graded Coexpression of Ion Channel, Neurofilament, and Synaptic Genes in Fast-Spiking Vestibular Nucleus Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Scaling Our World View: How Monoamines Can Put Context Into Brain Circuitry.Frontiers in cellular neuroscience · 2018Article
- Structural Properties of Synaptic Transmission and Temporal Dynamics at Excitatory Layer 5B Synapses in the Adult Rat Somatosensory Cortex.Frontiers in synaptic neuroscience · 2018Article
- Article
- Phase changes in neuronal postsynaptic spiking due to short term plasticity.PLoS computational biology · 2017Article
- Synaptic Specializations Support Frequency-Independent Purkinje Cell Output from the Cerebellar Cortex.Cell reports · 2016Article
- Fatigue in Rapsyn-Deficient Zebrafish Reflects Defective Transmitter Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
- Spontaneous Activity Defines Effective Convergence Ratios in an Inhibitory Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Signal transfer in neural circuits is dynamically modified by the recent history of neuronal activity. Short-term plasticity endows synapses with nonlinear transmission properties, yet synapses in sensory and motor circuits are capable of signaling linearly over a wide range of presynaptic firing rates. How do such synapses achieve rate-invariant transmission despite history-dependent nonlinearities? Here, ultrastructural, biophysical, and computational analyses demonstrate that concerted molecular, anatomical, and physiological refinements are required for central vestibular nerve synapses to linearly transmit rate-coded sensory signals. Vestibular synapses operate in a physiological regime of steady-state depression imposed by tonic firing. Rate-invariant transmission relies on brief presynaptic action potentials that delimit calcium influx, large pools of rapidly mobilized vesicles, multiple low-probability release sites, robust postsynaptic receptor sensitivity, and efficient transmitter clearance. Broadband linear synaptic filtering of head motion signals is thus achieved by coordinately tuned synaptic machinery that maintains physiological operation within inherent cell biological limitations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.