ArticlePsychoneuroendocrinology2015
Differential associations between childhood trauma subtypes and adolescent HPA-axis functioning.
Article in Psychoneuroendocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
73 citing papers in PubMed, 4 syntheses or guidelines pooled it, 175 citations in OpenAlex.
- The Dynamic Interplay Between Puberty and Structural Brain Development as a Predictor of Mental Health Difficulties in Adolescence: A Systematic Review.Biological psychiatry · 2024Pooled it
- Early life adversity exposure and circulating markers of inflammation in children and adolescents: A systematic review and meta-analysis.Brain, behavior, and immunity · 2020Pooled it
- Psychosocial functioning and the cortisol awakening response: Meta-analysis, P-curve analysis, and evaluation of the evidential value in existing studies.Biological psychology · 2017Pooled it
- Is HPA axis reactivity in childhood gender-specific? A systematic review.Biology of sex differences · 2017Pooled it
- Early life stress sensitizes youth to the influence of stress-induced cortisol on memory for affective words.Developmental psychobiology · 2021Trial
- Endogenous in-session cortisol during exposure therapy predicts symptom improvement: Preliminary results from a scopolamine-augmentation trial.Psychoneuroendocrinology · 2020Trial
- Family structure, depressive symptoms, and childhood maltreatment in Chinese adolescents: a mediation analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Differential associations between early life adversity subtypes and adolescent stress reactivity across neuroendocrine, autonomic, immune, and metabolic systems.Neurobiology of stress · 2026Article
- Mixed evidence for stress effects on cortisol-testosterone coupling in Syrian refugee and Jordanian non-refugee adolescents.Psychoneuroendocrinology · 2026Article
- Testing the Indirect Effects of Sense of Control & Perceived Stress in the Relationship between Child Abuse History & Intimate Partner Violence Perpetration in Adulthood.Journal of family violence · 2025Article
- Article
- Sleep duration in adolescence buffers the impact of childhood trauma on anxiety and depressive symptoms.BMC public health · 2025Article
- Childhood trauma is associated with perceived stress and hair cortisol levels characterized by the BDNF Val66Met genotype and sex.Frontiers in psychiatry · 2025Article
- Gender differences of neurometabolic and neuroendocrine alternations and its lateralization in adolescents with major depressive disorder.BMC psychiatry · 2024Article
- Child Temperamental Negative Affectivity Moderates the Relation between Interparental Conflict and Child Cortisol Recovery.Social development (Oxford, England) · 2024Article
- Let it go, let it go: Stop measuring child maltreatment as a binary yes/no.Child abuse & neglect · 2024Review
- Association between negative life events through mental health and non-suicidal self-injury with young adults: evidence for sex moderate correlation.BMC psychiatry · 2024Article
- Pitfalls and potential: Translating the two-hit model of early life stress from pre-clinical non-human experiments to human samples.Brain, behavior, & immunity - health · 2024Article
- Inflammatory burden of adolescents with childhood maltreatment: results from baseline data of a school cohort.European child & adolescent psychiatry · 2024Article
- Bridging childhood to adulthood: the impact of early life stress on acute stress responses.Frontiers in psychiatry · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledStudies examining the association between childhood trauma exposure and neuroendocrine functioning have returned inconsistent findings. To date, few studies have accounted for the role exposure to different types of childhood trauma may have on different neuroendocrine adaptations, and no study has examined this association using multiple indices of hypothalamic-pituitary-adrenal axis (HPA-axis) functioning. The purpose of this study was to characterize the unique associations between exposure to physical abuse, emotional abuse, and non-intentional trauma, and multiple indices of HPA-axis functioning.
methodsA community sample of 138 youth (aged 9-16) completed the Socially Evaluated Cold Pressor Task (SE-CPT) while their parents completed the Early Trauma Inventory (ETI). All youth then collected 4 diurnal salivary cortisol samples at home across 2 consecutive weekdays.
resultsHigh reported exposure to non-intentional trauma was associated with intact diurnal regulation but elevated cortisol at bedtime, physical abuse was associated with faster reactivity to acute stress, and emotional abuse was associated with delayed recovery of cortisol following acute stress. Taken together, there was a heterogeneous relationship among different indices of HPA-axis functioning and trauma subtype. DISCUSSION: Different types of childhood trauma exposure are related to distinct anomalies in HPA-axis functioning. This study underscores the importance of research incorporating multiple indices of HPA-axis functioning to inform our understanding of the underlying neuroendocrine dysregulation that may later lead to stress-related psychopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.