ArticleHuman brain mapping2015
Cerebellar gray and white matter volume and their relation with age and manual motor performance in healthy older adults.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 68 citations in OpenAlex.
- Enhancing Balance Control in Aging Through Cerebellar Theta-Burst Stimulation.Cerebellum (London, England) · 2025Trial
- Compared motor learning effects of motor cortical and cerebellar repetitive transcranial magnetic stimulation during a serial reaction time task in older adults.Scientific reports · 2025Trial
- Course induced dexterity development and cerebellar grey matter growth of dentistry students: a randomised trial.Scientific reports · 2021Trial
- Exercise effects on bed rest-induced brain changes.PloS one · 2018Trial
- Anterior Superior Longitudinal Fasciculus Microstructure Correlates With Bimanual Visuomotor Performance in Healthy Younger but Not Older Adults.The European journal of neuroscience · 2026Article
- Multivariate associations of motor performance, sleep quality, depressive symptoms, and grey matter volume in younger and mid-to-older adults.Scientific reports · 2026Article
- Age- and sex-divergent neurodevelopmental patterns revealed through structural magnetic resonance imaging features.Frontiers in neuroanatomy · 2026Article
- Dose-Response Association between Hand Dexterity and Functional Disability: A Longitudinal Study from the Kasama Study.Annals of geriatric medicine and research · 2025Article
- Cerebellar White Matter Microstructure Is Associated With Age, Cerebrospinal Fluid Amyloid Beta Levels, and Cognition in Cognitively Unimpaired Older Adults.Human brain mapping · 2025Article
- Global Neurocognitive and Emotional Dysfunction in Fanconi Anemia: A Neuropsychological Case Report of a 39-Year-Old Patient.Case reports in neurological medicine · 2025Article
- Functional and structural cerebellar-behavior relationships in aging.Brain structure & function · 2024Article
- Sex as a Determinant of Age-Related Changes in the Brain.International journal of molecular sciences · 2024Review
- Lower motor performance is linked with poor sleep quality, depressive symptoms, and grey matter volume alterations.bioRxiv : the preprint server for biology · 2024Article
- Cerebellum and Aging: Update and Challenges.Aging and disease · 2024Review
- Microstructural neural correlates of maximal grip strength in autistic children: the role of the cortico-cerebellar network and attention-deficit/hyperactivity disorder features.Frontiers in integrative neuroscience · 2024Article
- Classification of Mild Cognitive Impairment and Alzheimer's Disease Using Manual Motor Measures.Neuro-degenerative diseases · 2024Article
- How we get a grip: Microstructural neural correlates of manual grip strength in children.NeuroImage · 2023Article
- Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memory.NeuroImage · 2023Article
- Volumetric regional MRI and neuropsychological predictors of motor task variability in cognitively unimpaired, Mild Cognitive Impairment, and probable Alzheimer's disease older adults.Experimental gerontology · 2023Article
- Dependence and reduced motor function in heart failure: future directions for well-being.Heart failure reviews · 2022Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesFunctional neuroimaging and voxel-based morphometry studies have confirmed the important role of the cerebellum in motor behavior. However, little is known about the relationship between cerebellar gray (GMv) and white matter (WMv) volume and manual motor performance in aging individuals. This study aims to quantify the relationship between cerebellar tissue volume and manual motor performance. EXPERIMENTAL
designTo gain more insight into cerebellar function and how it relates to the role of the primary motor cortex (M1), we related cerebellar GMv, WMv, and M1v to manual motor performance in 217 healthy older individuals. Left and right cerebellar GMv and WMv, and M1v were obtained using FreeSurfer. The following motor measures were obtained: grip force, tapping speed, bimanual visuomotor coordination, and manual dexterity. PRINCIPAL OBSERVATIONS: Significant positive relationships were observed between cerebellar GMv and WMv and grip strength, right cerebellar WMv and right-hand tapping speed, right cerebellar WMv and dexterity, M1v and grip strength, and right M1v and left-hand dexterity, though effect sizes were small.
conclusionsOur results show that cerebellar GMv and WMv are differently associated with manual motor performance. These associations partly overlap with the brain-behavior associations between M1 and manual motor performance. Not all observed associations were lateralized (i.e., ipsilateral cerebellar and contralateral M1v associations with motor performance), which could point to age-related neural dedifferentiation. The current study provides new insights in the role of the cerebellum in manual motor performance. In consideration of the small effect sizes replication studies are needed to validate these results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.