ArticleHuman brain mapping2015
Enhanced neural responsiveness to reward associated with obesity in the absence of food-related stimuli.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Differentiating the abnormalities of food and monetary reward cue processing associated with overweight/obesity: an ALE meta-analysis.International journal of obesity (2005) · 2026Pooled it
- Oxytocin Administration Increases Proactive Control in Men with Overweight or Obesity: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.Obesity (Silver Spring, Md.) · 2021Trial
- The Effects of a 12-Month Weight Loss Intervention on Cognitive Outcomes in Adults with Overweight and Obesity.Nutrients · 2020Trial
- An open-label pilot study of psilocybin-assisted therapy for binge eating disorder.Journal of eating disorders · 2026Article
- Structural connectome manifold changes related to body mass index and their associations with eating psychopathology.NeuroImage. Clinical · 2025Article
- The macroscale routing mechanism of structural brain connectivity related to body mass index.Human brain mapping · 2024Article
- How movies move us - movie preferences are linked to differences in neuronal emotion processing of fear and anger: an fMRI study.Frontiers in behavioral neuroscience · 2024Article
- Higher body weight-dependent neural activation during reward processing.Brain imaging and behavior · 2023Article
- Testing reward processing models of obesity using in-the-moment assessments of subjective enjoyment of food and non-food activities.Eating behaviors · 2023Article
- Integrated multi-modal brain signatures predict sex-specific obesity status.Brain communications · 2023Article
- Could Alcohol Abuse and Dependence on Junk Foods Inducing Obesity and/or Illicit Drug Use Represent Danger to Liver in Young People with Altered Psychological/Relational Spheres or Emotional Problems?International journal of molecular sciences · 2022Review
- Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals.Molecular psychiatry · 2022Article
- Disrupted stepwise functional brain organization in overweight individuals.Communications biology · 2022Article
- Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders : Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group.Molecular psychiatry · 2021Article
- Inter-individual body mass variations relate to fractionated functional brain hierarchies.Communications biology · 2021Article
- The endocannabinoid system in humans: significant associations between anandamide, brain function during reward feedback and a personality measure of reward dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Whole-brain functional connectivity correlates of obesity phenotypes.Human brain mapping · 2020Article
- African American Children's Diminished Returns of Subjective Family Socioeconomic Status on Fun Seeking.Children (Basel, Switzerland) · 2020Article
- Reward Responsiveness in the Adolescent Brain Cognitive Development (ABCD) Study: African Americans' Diminished Returns of Parental Education.Brain sciences · 2020Article
- Enhanced Go and NoGo Learning in Individuals With Obesity.Frontiers in behavioral neuroscience · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity has been characterized by alterations in brain structure and function associated with emotion processing and regulation. Particularly, aberrations in food-related reward processing have been frequently demonstrated in obese subjects. However, it remains unclear whether reward-associated functional aberrations in obesity are specific for food-related stimuli or represent a general deficit in reward processing, extending to other stimulus domains. Given the crucial role of rewarding effects in the development of obesity and the ongoing discussion on overlapping neurobiological traits of obesity and psychiatric disorders such as depression and substance-related disorders, this study aimed to investigate the possibility of altered reward processing in obese subjects to occur in the absence of food-related stimuli during a monetary reward condition.
methodsTwenty-nine healthy obese subjects (body mass index >30) and 29 healthy, age-, and sex-matched control subjects of normal weight underwent functional MRI during a frequently used card guessing paradigm. A Group × Condition (win vs. loss) ANOVA was conducted to investigate differences between obese and normal-weight subjects.
resultsWe found significant Group × Condition interaction effects in brain areas involved in emotion regulation and reward processing including the insula, the striatum, and the orbitofrontal cortex (OFC). This interaction was predominantly driven by a significant increase in blood oxygenation level dependent (BOLD) response in obese individuals while experiencing reward.
conclusionsEnhanced neural activation in obesity during reward processing seems to be apparent even in the absence of food-related stimuli and, thus, might point to generalized dysfunctions in reward-related brain circuits in obese individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.