Evidence map›Paper›PMID 25704502›Full record

ReviewImmunology letters2015

A re-evaluation of the role of B cells in protective immunity to Chlamydia infection.

Lin-Xi Li, Stephen J McSorley

Open access · greenAbstract readReview
In one paragraph

Review in Immunology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Reduction ofVaccine: X · 2023
    Article
  6. Article
  7. Vaginal delivery of vaccines.Advanced drug delivery reviews · 2021
    Review
  8. Circulating immunity protects the female reproductive tract fromProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. NK Cells Contribute to Protective Memory T Cell Mediated Immunity toFrontiers in cellular and infection microbiology · 2020
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lin-Xi LiCenter for Comparative Medicine, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, United States. Electronic address: lxli@ucdavis.edu.
Stephen J McSorleyCenter for Comparative Medicine, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, United States.
University of California, Davis · US

Funding

CD4 T Cell Response to SalmonellaR01AI055743 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCSORLEY, STEPHEN J · 2004 to 2013
$3.5M
Typhoid priority antigen identification and vaccine developmentR01AI073672 · NIAID · UNIVERSITY OF MINNESOTA · PI MCSORLEY, STEPHEN J · 2008 to 2011
$1.6M
Generation of a TCR transgenic mouse to study Chlamydia genital tract infectionR21AI117303 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCSORLEY, STEPHEN J · 2015 to 2016
$422k
NIAID NIH HHS AI117303NIAID NIH HHS R01 AI055743NIAID NIH HHS R01 AI073672NIAID NIH HHS R21 AI117303
6 · The paper itself

Abstract

Chlamydia trachomatis is the etiological agent of the most commonly reported bacterial sexual transmitted infection (STI) in North America and Europe. The control of Chlamydia infection is hindered by the asymptomatic nature of initial infection but the consequence of untreated infection seriously threatens the reproductive health of young women. Unfortunately, there is no licensed vaccine for Chlamydia vaccine, in part due to our incomplete understanding of the immune response to Chlamydia urogenital infection. It has been well established that T cell-mediated immunity plays a dominant role in protective immunity against Chlamydia and thus the importance of B cells is somewhat underappreciated. Here, we summarize recent progress on understanding the role of B cells during Chlamydia genital tract infections and discuss how B cells and humoral immunity make an effective contribution to host defense against important intracellular pathogens, including Chlamydia.

Indexed as

Biological EvolutionImmunityAnimalsAntibodies, BacterialB-LymphocytesChlamydia InfectionsChlamydia trachomatisDisease Models, AnimalHost-Pathogen InteractionsHumansMiceAntibodies, BacterialAntibodyB cellsChlamydiaIntracellular infections

Identifiers

PMID25704502
PMCPMC4402208
OpenAlexW2048571906

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.