ArticleSurgery2015
Enteral nutrient deprivation in patients leads to a loss of intestinal epithelial barrier function.
Article in Surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 83 citations in OpenAlex.
- Gastrointestinal Dysfunction in Critically Ill Patients With Traumatic Brain Injury: Clinical Implications and Putative Mechanisms: a Narrative Review.Current neurology and neuroscience reports · 2026Review
- Ileostoma as a promising tool in pathophysiological study and clinical intervention: a review from bench to beside.Frontiers in immunology · 2026Review
- Farnesoid X Receptor Agonist Tropifexor Improves Intestinal Defense Response and Epithelial Barrier Function in Neonatal Piglets Receiving Parenteral Nutrition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Post-endoscopic fever and infection in paediatric patients with intestinal failure.Journal of pediatric gastroenterology and nutrition · 2025Observational
- Propensity score-matched analysis of risk factors for prolonged postoperative ileus after TME in rectal cancer.Techniques in coloproctology · 2025Article
- Association between early enteral nutrition and 28-Day mortality in mechanically ventilated patients with sepsis: a retrospective analysis of the MIMIC-IV database.BMC infectious diseases · 2025Observational
- An Amino Acids and Dipeptide Injection Inhibits the TNF-α/HMGB1 Inflammatory Signaling Pathway to Reduce Pyroptosis and M1 Microglial Polarization in POCD Mice: the Gut to the Brain.Molecular neurobiology · 2024Article
- Early versus delayed enteral nutrition in ICU patients with sepsis: a propensity score-matched analysis based on the MIMIC-IV database.Frontiers in nutrition · 2024Article
- Nutrition support and clinical outcomes following allogeneic stem cell transplantation.Bone marrow transplantation · 2023Article
- Impact of Intensive Care Unit Nutrition on the Microbiome and Patient Outcomes.Anesthesiology clinics · 2023Review
- The central and biodynamic role of gut microbiota in critically ill patients.Critical care (London, England) · 2022Review
- Gastrointestinal manifestations and possible mechanisms of COVID-19 in different periods.Journal of digestive diseases · 2021Review
- Fiber in the ICU: Should it Be a Regular Part of Feeding?Current gastroenterology reports · 2021Review
- Small Bowel Resection Increases Paracellular Gut Barrier Permeability via Alterations of Tight Junction Complexes Mediated by Intestinal TLR4.The Journal of surgical research · 2021Article
- Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury.Frontiers in microbiology · 2021Review
- Nutrition in the Neurocritical Care Unit: a New Frontier.Current treatment options in neurology · 2021Review
- Opportunities and Challenges for Gut Microbiota in Acute Leukemia.Frontiers in oncology · 2021Review
- Microbiota-based approaches to mitigate infectious complications of intensive chemotherapy in patients with acute leukemia.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Percutaneous endoscopic gastrostomy - Too often? Too late? Who are the right patients for gastrostomy?World journal of gastroenterology · 2020Review
- Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine.Critical care (London, England) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the effect of nutrient withdrawal on human intestinal epithelial barrier function (EBF). We hypothesized that unfed mucosa results in decreased EBF. This was tested in a series of surgical small intestinal resection specimens.
designSmall bowel specifically excluding inflamed tissue, was obtained from pediatric patients (aged 2 days to 19 years) undergoing intestinal resection. EBF was assessed in Ussing chambers for transepithelial resistance (TER) and passage of fluorescein isothiocyanate (FITC)-dextran (4 kD). Tight junction and adherence junction proteins were imaged with immunofluorescence staining. Expression of Toll-like receptors (TLR) and inflammatory cytokines were measured in loop ileostomy takedowns in a second group of patients.
resultsBecause TER increased with patient age (P < .01), results were stratified into infant versus teenage groups. Fed bowel had significantly greater TER versus unfed bowel (P < .05) in both age populations. Loss of EBF was also observed by an increase in FITC-dextran permeation in enteral nutrient-deprived segments (P < .05). Immunofluorescence staining showed marked declines in intensity of ZO-1, occludin, E-cadherin, and claudin-4 in unfed intestinal segments, as well as a loss of structural formation of tight junctions. Analysis of cytokine and TLR expression showed significant increases in tumor necrosis factor (TNF)-α and TLR4 in unfed segments of bowel compared with fed segments from the same individual.
conclusionEBF declined in unfed segments of human small bowel. This work represents the first direct examination of EBF from small bowel derived from nutrient-deprived humans and may explain the increased incidence of infectious complications seen in patients not receiving enteral feeds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.