ArticleNeuroImage2015
Functional subdivision of the human periaqueductal grey in respiratory control using 7 tesla fMRI.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 75 citations in OpenAlex.
- Trial
- Dyspnea-related cues engage the prefrontal cortex: evidence from functional brain imaging in COPD.Chest · 2015Trial
- Article
- MRI methods for the study of central nervous system involvement in autonomic function.Frontiers in network physiology · 2026Review
- Ultra-high field brain MRI for functional neurological disorder: opportunities and challenges.NeuroImage. Clinical · 2026Review
- Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns.bioRxiv : the preprint server for biology · 2025Article
- Distinguishing the activity of adjacent somatosensory nuclei within the brainstem using 3T fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Simultaneous cortical, subcortical, and brainstem mapping of sensory activation.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Simultaneous cortical, subcortical, and brainstem mapping of sensory activation.bioRxiv : the preprint server for biology · 2024Article
- Functional representation of trigeminal nociceptive input in the human periaqueductal gray.Science advances · 2024Article
- Single neurons in the thalamus and subthalamic nucleus process cardiac and respiratory signals in humans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The widespread action observation/execution matching system for facial expression processing.Human brain mapping · 2023Article
- Mapping internal brainstem structures using T1 and T2 weighted 3T images.Frontiers in neuroimaging · 2023Article
- Opioid analgesia alters corticospinal coupling along the descending pain system in healthy participants.eLife · 2022Article
- A 7-Tesla MRI study of the periaqueductal gray: resting state and task activation under threat.Social cognitive and affective neuroscience · 2022Article
- Article
- Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response.Progress in neurobiology · 2021Review
- Brainstem Mechanisms of Pain Modulation: A within-Subjects 7T fMRI Study of Placebo Analgesic and Nocebo Hyperalgesic Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Human Primary Olfactory Amygdala Subregions Form Distinct Functional Networks, Suggesting Distinct Olfactory Functions.Frontiers in systems neuroscience · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The periaqueductal grey (PAG) is a nucleus within the midbrain, and evidence from animal models has identified its role in many homeostatic systems including respiration. Animal models have also demonstrated a columnar structure that subdivides the PAG into four columns on each side, and these subdivisions have different functions with regard to respiration. In this study we used ultra-high field functional MRI (7 T) to image the brainstem and superior cortical areas at high resolution (1mm(3)voxels), aiming to identify activation within the columns of the PAG associated with respiratory control. Our results showed deactivation in the lateral and dorsomedial columns of the PAG corresponding with short (~10s) breath holds, along with cortical activations consistent with previous respiratory imaging studies. These results demonstrate the involvement of the lateral and dorsomedial PAG in the network of conscious respiratory control for the first time in humans. This study also reveals the opportunities of 7 T functional MRI for non-invasively investigating human brainstem nuclei at high-resolutions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.