ArticleActa paediatrica (Oslo, Norway : 1992)2015
Genes determining the severity of cerebral palsy: the role of single nucleotide polymorphisms on the amount and structure of apolipoprotein E.
Article in Acta paediatrica (Oslo, Norway : 1992), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Chinese expert consensus on the diagnostic definition of cerebral palsy.BMJ paediatrics open · 2026Article
- Association of Nogo-A Gene Polymorphisms with Cerebral Palsy in Southern China: A Case-Control Study.Developmental neuroscience · 2023Article
- The Role of Neuroimaging and Genetic Analysis in the Diagnosis of Children With Cerebral Palsy.Frontiers in neurology · 2020Article
- Review
- The complex aetiology of cerebral palsy.Nature reviews. Neurology · 2018Review
- Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort.BioMed research international · 2017Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
aimApolipoprotein E (apoE) influences repair and other processes in the brain, and the apoE4 variant is a risk factor for Alzheimer's disease and for prolonged recovery following traumatic brain injury. We previously reported that specific single nucleotide polymorphisms in the APOE or TOMM40 genes affecting the structure and production of apoE were associated with epilepsy, more impaired hand function and gastrostomy tube feeding in children with cerebral palsy (CP). This study explored how various combinations of the same polymorphisms may affect these clinical manifestations.
methodsSuccessful DNA analyses of APOE and TOMM40 were carried out on 227 children. The CP Register of Norway provided details of gross and fine motor function, epilepsy and gastrostomy tube feeding. Possible associations between these clinical manifestations and various combinations of the APOEε2, ε3 or ε4 alleles and of the rs59007384 polymorphism in the TOMM40 gene were explored.
resultsEpilepsy, impaired fine motor function and gastrostomy tube feeding were less common in children carrying the combination of rs59007384 GG and APOEε2 or ε3 than in children with other combinations.
conclusionOur findings suggest that specific combinations of genes influence the structure and production of apoE differently and affect the clinical manifestations of CP.
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