Evidence map›Paper›PMID 25703628›Full record

ReviewCurrent opinion in cell biology2015

Mitochondrial division and fusion in metabolism.

Madhuparna Roy, P Hemachandra Reddy, Miho Iijima, Hiromi Sesaki

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 200 citations in OpenAlex.

  1. Phytochemical Profile and Bioactive Potential ofAntioxidants (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Madhuparna RoyDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
P Hemachandra ReddyGarrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, United States.
Miho IijimaDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Hiromi SesakiDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: hsesaki@jhmi.edu.
Johns Hopkins University · USInstitute on Aging · USJohns Hopkins Medicine · US

Funding

JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI AHIMA, REXFORD S. · 2013 to 2017
$9.7M
Lipid Signaling in ChemotaxisR01GM084015 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI IIJIMA, MIHO · 2009 to 2019
$2.9M
Mitochondrial Fusion and DivisionR01GM089853 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SESAKI, HIROMI · 2010 to 2014
$2.1M
Dynamin-Related Protein 1 and Mitochondrial Fragmentation in Alzheimer's DiseaseR01AG042178 · NIA · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI REDDY, P. HEMACHANDRA · 2012 to 2016
$2.0M
Voltage-Dependent Anion Channel and Neurodegeneration in Alzheimer's DiseaseR01AG047812 · NIA · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI REDDY, P. HEMACHANDRA · 2014 to 2018
$1.9M
Introducing Mitochondrial Stasis in NeuronsR21NS084154 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SESAKI, HIROMI · 2013 to 2014
$443k
NIA NIH HHS AG042178NIA NIH HHS AG047812NIA NIH HHS R01 AG042178NIA NIH HHS R01 AG047812NIDDK NIH HHS P30 DK079637NIGMS NIH HHS GM084015NIGMS NIH HHS GM089853NIGMS NIH HHS R01 GM084015NIGMS NIH HHS R01 GM089853NINDS NIH HHS NS084154NINDS NIH HHS R21 NS084154
6 · The paper itself

Abstract

Mitochondria govern many metabolic processes. In addition, mitochondria sense the status of metabolism and change their functions to regulate energy production, cell death, and thermogenesis. Recent studies have revealed that mitochondrial structural remodeling through division and fusion is critical to the organelle's function. It has also become clear that abnormalities in mitochondrial division and fusion are linked to the pathophysiology of metabolic diseases such as diabetes and obesity. Here, we discuss the current understanding of the mechanisms of mitochondrial dynamics and their role in cellular and organismal metabolism.

Indexed as

MetabolismMitochondrial DynamicsDiabetes MellitusHumansMitochondriaObesity

Identifiers

PMID25703628
PMCPMC4380865
OpenAlexW2073902042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.