ArticleNeurogastroenterology and motility2015
Effect of experimental stress on the small bowel and colon in healthy humans.
Article in Neurogastroenterology and motility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Application of In Vivo MRI Imaging to Track a Coated Capsule and Its Disintegration in the Gastrointestinal Tract in Human Volunteers.Pharmaceutics · 2022Article
- The role of artificial intelligence in colon polyps detection.Gastroenterology and hepatology from bed to bench · 2020Review
- MRI of the Colon in the Pharmaceutical Field: The Future before us.Pharmaceutics · 2019Review
- Will MRI of gastrointestinal function parallel the clinical success of cine cardiac MRI?The British journal of radiology · 2019Review
- Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract.Current molecular pharmacology · 2018Review
- Small Bowel Motility.Current gastroenterology reports · 2017Review
- Genes, emotions and gut microbiota: The next frontier for the gastroenterologist.World journal of gastroenterology · 2017Review
- Distinct Abnormalities of Small Bowel and Regional Colonic Volumes in Subtypes of Irritable Bowel Syndrome Revealed by MRI.The American journal of gastroenterology · 2017Observational
- Corticotropin-releasing hormone receptor 1 (CRH-R1) polymorphisms are associated with irritable bowel syndrome and acoustic startle response.Psychoneuroendocrinology · 2016Article
- The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression.Psychoneuroendocrinology · 2016Article
- Mechanism-Oriented Therapy of Irritable Bowel Syndrome.Advances in therapy · 2016Review
- Neuroimmune pharmacological approaches.Current opinion in pharmacology · 2015Review
- Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution.World journal of gastrointestinal pathophysiology · 2015Review
- Effect of experimental stress on the small bowel and colon in healthy humans.Neurogastroenterology and motility · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSymptoms of irritable bowel syndrome (IBS) are frequently reported to be exacerbated by stress. Animal studies suggest that corticotrophin releasing hormone (CRH) mediates the effect of stress on the bowel. We have shown that stressed IBS patients with diarrhea have constricted small bowels. We hypothesized that we could mimic this effect by applying experimental stress in the form of either hand immersion in ice water or CRH injection in healthy volunteers (HV).
methodsThe postprandial effect of the cold pressor test (repeated hand immersion in ice cold water) and injection of CRH, were assessed vs control in two groups of 18 HVs. KEY
resultsCRH produced a significant rise from baseline salivary cortisol levels (p = 0.004) not seen with the cold pressor test. Small bowel water content (SBWC) fell postprandially on all four treatments. SBWC was significantly reduced by both stressors but CRH caused a greater effect (anova, p < 0.003 vs p = 0.02). Ascending colon (AC) volume was greater after CRH injection compared with saline (p = 0.002) but no differences were seen with the cold pressor test vs warm water. Postprandial increase in colon volume was also reduced by CRH which also increased the sensations of distension and bloating. CONCLUSIONS & INFERENCES: Two experimental stressors were shown to constrict the small bowel, mimicking the effect previously seen in IBS-D patients. CRH increased the volume of the AC. We speculate that stress accelerates transfer of water from the small bowel to the AC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.