Evidence map›Paper›PMID 25703559›Full record

ReviewImmunological reviews2015

B cells and antibodies in the defense against Mycobacterium tuberculosis infection.

Jacqueline M Achkar, John Chan, Arturo Casadevall

Abstract readReview
In one paragraph

Review in Immunological reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Blood transcriptomic signatures distinguishEmerging microbes & infections · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. A proteome-wide atlas of humoral immunity toFrontiers in immunology · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Spatial microbiome-metabolic crosstalk drives CD8Frontiers in microbiology · 2025
    Article
  17. Article
  18. Review
  19. Editorial: Tuberculosis and humoral immunity.Frontiers in immunology · 2025
    Article
  20. Article

65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jacqueline M AchkarDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
John Chan
Arturo Casadevall

Funding

Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Immunology/Pathology CoreP30AI051519 · NIAID · YESHIVA UNIVERSITY · PI GOLDSTEIN, HARRIS · 2003 to 2013
$18.6M
"The Tuberculous Granuloma"P01AI063537 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI CHAN, JOHN R. · 2005 to 2015
$15.7M
Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONSR01AI033774 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2014
$5.6M
Molecular Characterization of C. neoformans AntibodiesR37AI033142 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2007 to 2016
$3.9M
B cells and humoral immunity in tuberculosisR01AI094745 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHAN, JOHN R. · 2012 to 2016
$3.2M
MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIESR01AI033142 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2006
$1.7M
Antibody Biomarkers for Early Detection of TuberculosisR01AI096213 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MAGEE, D MITCHELL · 2011 to 2012
$1.0M
Discovery of Biological and Immunological Biomarkers for TB VaccinesU18FD004012 · FDA · AERAS · PI BRENNAN, MICHAEL · 2010 to 2012
$853k
Novel serological biomarker for rapid tuberculosis diagnosisR21AI105684 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ACHKAR, JACQUELINE MICHELE · 2013 to 2014
$444k
FDA HHS 1U18 FD004012/01FDA HHS U18 FD004012NCATS NIH HHS UL1 TR001073NHLBI NIH HHS HL-059842NHLBI NIH HHS R01 HL059842NIAID NIH HHS AI-033142NIAID NIH HHS AI-033774NIAID NIH HHS AI-052733NIAID NIH HHS AI-063537NIAID NIH HHS AI-094745NIAID NIH HHS AI-096213NIAID NIH HHS AI-51519NIAID NIH HHS P01 AI063537NIAID NIH HHS P30 AI051519NIAID NIH HHS R01 AI033142NIAID NIH HHS R01 AI033774NIAID NIH HHS R01 AI052733NIAID NIH HHS R01 AI094745NIAID NIH HHS R01 AI096213NIAID NIH HHS R21 AI105684NIAID NIH HHS R37 AI033142
6 · The paper itself

Abstract

Better understanding of the immunological components and their interactions necessary to prevent or control Mycobacterium tuberculosis (Mtb) infection in humans is critical for tuberculosis (TB) vaccine development strategies. Although the contributory role of humoral immunity in the protection against Mtb infection and disease is less defined than the role of T cells, it has been well-established for many other intracellular pathogens. Here we update and discuss the increasing evidence and the mechanisms of B cells and antibodies in the defense against Mtb infection. We posit that B cells and antibodies have a variety of potential protective roles at each stage of Mtb infection and postulate that such roles should be considered in the development strategies for TB vaccines and other immune-based interventions.

Indexed as

Immunity, HumoralAnimalsAntibodies, BacterialB-LymphocytesCell CommunicationHost-Pathogen InteractionsHumansImmunity, CellularImmunity, InnateMycobacterium tuberculosisTuberculosisTuberculosis VaccinesAntibodies, BacterialTuberculosis VaccinesantibodiesB lymphocytesimmunityimmunoglobulinstuberculosis

Identifiers

PMID25703559
PMCPMC4629253

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.