ArticleClinical radiology2015
Obesity and extent of emphysema depicted at CT.
Article in Clinical radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- HighERJ open research · 2026Article
- High BMI and COPD Outcomes in Alpha-1 Antitrypsin Deficiency.CHEST pulmonary · 2025Article
- A machine learning model and identification of immune infiltration for chronic obstructive pulmonary disease based on disulfidptosis-related genes.BMC medical genomics · 2025Article
- Association Between Weight-Adjusted Waist Index and Emphysema in Adults in the United States: A Cross-Sectional Study Involving 44,949 Participants.Advances in respiratory medicine · 2024Article
- Skin Markers of Premature Ageing in Patients with COPD: Results Form COSYCONET.Journal of clinical medicine · 2024Article
- Obesity Impact on Dyspnea in COPD Patients.International journal of chronic obstructive pulmonary disease · 2024Observational
- Obesity Paradox in Lung Diseases: What Explains It?Obesity facts · 2023Review
- A comparative study of chest CT findings regarding the effects of regional dust exposure on patients with COPD living in urban areas and rural areas near cement plants.Respiratory research · 2021Article
- Obesity and Morbidity Risk in the U.S. Veteran.Healthcare (Basel, Switzerland) · 2020Article
- Investigation of the Obesity Paradox in Chronic Obstructive Pulmonary Disease, According to Smoking Status, in the United States.American journal of epidemiology · 2019Article
- Using a spatial point process framework to characterize lung computed tomography scans.Spatial statistics · 2019Article
- Dietary ω-6 polyunsaturated fatty acid arachidonic acid increases inflammation, but inhibits ECM protein expression in COPD.Respiratory research · 2018Article
- Gender and asthma-chronic obstructive pulmonary disease overlap syndrome.The Journal of asthma : official journal of the Association for the Care of Asthma · 2016Article
- Sex differences of COPD phenotypes in nonsmoking patients.International journal of chronic obstructive pulmonary disease · 2016Article
- Emphysema prevalence related air pollution caused by a cement plant.Annals of occupational and environmental medicine · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
aimTo investigate the underlying relationship between obesity and the extent of emphysema depicted at CT. METHODS AND MATERIALS: A dataset of 477 CT examinations was retrospectively collected from a study of chronic obstructive pulmonary disease (COPD). The low attenuation areas (LAAs; ≤950 HU) of the lungs were identified. The extent of emphysema (denoted as %LAA) was defined as the percentage of LAA divided by the lung volume. The association between log-transformed %LAA and body mass index (BMI) adjusted for age, sex, the forced expiratory volume in one second as percent predicted value (FEV1% predicted), and smoking history (pack years) was assessed using multiple linear regression analysis.
resultsAfter adjusting for age, gender, smoking history, and FEV1% predicted, BMI was negatively associated with severe emphysema in patients with COPD. Specifically, one unit increase in BMI is associated with a 0.93-fold change (95% CI: 0.91-0.96, p<0.001) in %LAA; the estimated %LAA for males was 1.75 (95% CI: 1.36-2.26, p<0.001) times that of females; per 10% increase in FEV1% predicated is associated with a 0.72-fold change (95% CI: 0.69-0.76, p<0.001) in %LAA.
conclusionIncreasing obesity is negatively associated with severity of emphysema independent of gender, age, and smoking history.
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