ArticleEpidemiology and infection2015
Increased prevalence of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2010 to 2012.
Article in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Predominance of M1European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Group A streptococcal primary peritonitis and toxic shock syndrome.Clinical journal of gastroenterology · 2025Article
- Emergence of clade 3Microbiology (Reading, England) · 2025Article
- Analysis ofmBio · 2025Article
- Streptococcal Toxic Shock Syndrome Caused by Cellulitis Following a Fall: A Report of Two Critical Cases.Cureus · 2025Article
- Trends in the growing impact of group A Streptococcus infection on public health after COVID-19 pandemic: a multicentral observational study in Okayama, Japan.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Observational
- A comprehensive analysis of antimicrobial resistance of clinicalJAC-antimicrobial resistance · 2025Article
- Cardiac rupture and toxic shock syndrome by invasive group a Streptococcus in a Fontan patient with Asplenia syndrome.Journal of cardiology cases · 2025Article
- Toxic Shock Syndrome (TSS) Caused by Group AJournal of Korean medical science · 2024Review
- A Review of the Impact of Streptococcal Infections and Antimicrobial Resistance on Human Health.Antibiotics (Basel, Switzerland) · 2024Review
- Article
- A Case Report of Rapidly Necrotizing Fasciitis Post-Falling Down Treated Reconstructively.Cureus · 2022Article
- Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test.Internal medicine (Tokyo, Japan) · 2021Article
- A Review ofPathogens (Basel, Switzerland) · 2021Review
- Clinical Characteristics of Necrotizing Soft Tissue Infection and Early Toxic Shock-Like Syndrome Caused by Group GKansas journal of medicine · 2021Article
- Genetic Characterization ofInfectious microbes & diseases · 2020Article
- Article
- Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment.Journal of innate immunity · 2020Article
- Streptococcus pyogenes Transcriptome Changes in the Inflammatory Environment of Necrotizing Fasciitis.Applied and environmental microbiology · 2019Article
- Colonization of β-hemolytic streptococci in patients with erysipelas-a prospective study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcal toxic shock syndrome (STSS) is a severe invasive infection characterized by the sudden onset of shock, multi-organ failure, and high mortality. In Japan, appropriate notification measures based on the Infectious Disease Control law are mandatory for cases of STSS caused by β-haemolytic streptococcus. STSS is mainly caused by group A streptococcus (GAS). Although an average of 60-70 cases of GAS-induced STSS are reported annually, 143 cases were recorded in 2011. To determine the reason behind this marked increase, we characterized the emm genotype of 249 GAS isolates from STSS patients in Japan from 2010 to 2012 and performed antimicrobial susceptibility testing. The predominant genotype was found to be emm1, followed by emm89, emm12, emm28, emm3, and emm90. These six genotypes constituted more than 90% of the STSS isolates. The number of emm1, emm89, emm12, and emm28 isolates increased concomitantly with the increase in the total number of STSS cases. In particular, the number of mefA-positive emm1 isolates has escalated since 2011. Thus, the increase in the incidence of STSS can be attributed to an increase in the number of cases associated with specific genotypes.
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