ArticleEpidemiology and infection2015
Diphtheria outbreak in Maranhão, Brazil: microbiological, clinical and epidemiological aspects.
Article in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Corynebacterium pseudodiphtheriticum as etiologic agent of human infections worldwide: a review of case reports within the last 40 years (1983-2023).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Review
- Virulence and mutations analysis based on the whole genome of a BrazilianFrontiers in microbiology · 2025Article
- Infection by a multidrug-resistant Corynebacterium diphtheriae strain: prediction of virulence factors, CRISPR-Cas system analysis, and structural implications of mutations conferring rifampin resistance.Functional & integrative genomics · 2024Article
- Molecular characterization and whole-genome sequencing of Corynebacterium diphtheriae causing skin lesion.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Phenotypic and molecular characterization and complete genome sequence of a Corynebacterium diphtheriae strain isolated from cutaneous infection in an immunized individual.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- A multiomic approach to defining the essential genome of the globally important pathogen Corynebacterium diphtheriae.PLoS genetics · 2023Article
- Diphtheria resurgence in Sada'a-Yemen, 2017-2020.BMC infectious diseases · 2022Article
- Epidemiology of Diphtheria in Yemen, 2017-2018: Surveillance Data Analysis.JMIR public health and surveillance · 2021Article
- Article
- Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae.Nature communications · 2021Article
- Cutaneous infection by non-diphtheria-toxin producing and penicillin-resistantAccess microbiology · 2021Article
- Triage in the Time of Diphtheria.The western journal of emergency medicine · 2020Article
- Whole-Genome Sequencing of Corynebacterium diphtheriae Isolates Recovered from an Inner-City Population Demonstrates the Predominance of a Single Molecular Strain.Journal of clinical microbiology · 2020Article
- Phenotypic and Genotypic Correlates of Penicillin Susceptibility in Nontoxigenic Corynebacterium diphtheriae, British Columbia, Canada, 2015-2018.Emerging infectious diseases · 2020Article
- First-line antibiotic susceptibility pattern of toxigenic Corynebacterium diphtheriae in Indonesia.BMC infectious diseases · 2019Observational
- Whole Genome Sequencing for Surveillance of Diphtheria in Low Incidence Settings.Frontiers in public health · 2019Review
- Genome-wide comparison of Corynebacterium diphtheriae isolates from Australia identifies differences in the Pan-genomes between respiratory and cutaneous strains.BMC genomics · 2018Article
- The C-terminal coiled-coil domain of Corynebacterium diphtheriae DIP0733 is crucial for interaction with epithelial cells and pathogenicity in invertebrate animal model systems.BMC microbiology · 2018Article
- Complete Closed Genome Sequence of Nontoxigenic InvasiveGenome announcements · 2018Article
- Genomic analysis of endemic clones of toxigenic and non-toxigenic Corynebacterium diphtheriae in Belarus during and after the major epidemic in 1990s.BMC genomics · 2017Article
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15 authors.
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Abstract
We describe microbiological, clinical and epidemiological aspects of a diphtheria outbreak that occurred in Maranhão, Brazil. The majority of the 27 confirmed cases occurred in partially (n = 16) or completely (n = 10) immunized children (n = 26). Clinical signs and characteristic symptoms of diphtheria such as cervical lymphadenopathy and pseudomembrane formation were absent in 48% and 7% of the cases, respectively. Complications such as paralysis of lower limbs were observed. Three cases resulted in death, two of them in completely immunized children. Microbiological analysis identified the isolates as Corynebacterium diphtheriae biovar intermedius with a predominant PFGE type. Most of them were toxigenic and some showed a decrease in penicillin G susceptibility. In conclusion, diphtheria remains endemic in Brazil. Health professionals need to be aware of the possibility of atypical cases of C. diphtheriae infection, including pharyngitis without pseudomembrane formation.
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