ArticleChemical communications (Cambridge, England)2015
Enzyme transformation to modulate the ligand-receptor interactions between small molecules.
Article in Chemical communications (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Applications of self-assembled peptide hydrogels in anti-tumor therapy.Nanoscale advances · 2024Review
- Supramolecular biofunctional materials.Biomaterials · 2017Review
- Ligand-Receptor Interaction Modulates the Energy Landscape of Enzyme-Instructed Self-Assembly of Small Molecules.Journal of the American Chemical Society · 2016Article
- The Enzyme-instructed assembly of the core of yeast prion Sup35 to form supramolecular hydrogels.Journal of materials chemistry. B · 2016Article
- Nanoscale Assemblies of Small Molecules Control the Fate of Cells.Nano today · 2015Article
- Supramolecular Detoxification of Neurotoxic Nanofibrils of Small Molecules via Morphological Switch.Bioconjugate chemistry · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Enzymatic transformation is a fundamental process to control ligand-receptor interactions among proteins for signal transduction in cells. Here we report the first example of enzymatic transformation regulated ligand-receptor interactions of small molecules, in which enzymatic reaction changes the stoichiometry of the ligand-receptor binding from 1 : 1 to 1 : 2. We also show that this unique integration of enzymatic transformation and ligand-receptor interactions of small molecules is able to affect the fate of cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.