ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Parabrachial Nucleus Contributions to Glucagon-Like Peptide-1 Receptor Agonist-Induced Hypophagia.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- The central amygdala gates exogenous glucagon-like peptide 1 signals.Molecular metabolism · 2026Article
- Parabrachial CGRP Neurons Regulate Opioid Reinforcement.bioRxiv : the preprint server for biology · 2026Article
- A key role for parabrachial nucleus CGRP neurons in FGF1-Induced anorexia.Molecular metabolism · 2025Article
- Integration of Glucagon-Like Peptide 1 Receptor Actions Through the Central Amygdala.Endocrinology · 2025Review
- Novel neural pathways targeted by GLP-1R agonists and bariatric surgery.Pflugers Archiv : European journal of physiology · 2025Review
- Licking microstructure behavior classifies a spectrum of emotional states in mice.Frontiers in systems neuroscience · 2025Article
- Synthetic exendin-4 disrupts responding to reward predictive incentive cues in male rats.Frontiers in behavioral neuroscience · 2024Article
- The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1.Science advances · 2023Article
- Glucagon-Like Peptide-1 Receptors in the Gustatory Cortex Influence Food Intake.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats.Science translational medicine · 2020Article
- Glucagon-like peptide 1 (GLP-1).Molecular metabolism · 2019 · on this mapReview
- GLP-1: Molecular mechanisms and outcomes of a complex signaling system.Neurochemistry international · 2019Review
- Amphetamine-induced activation of neurons within the rat nucleus of the solitary tract.Physiology & behavior · 2019Article
- Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment.Scientific reports · 2018Article
- Characterizing ingestive behavior through licking microstructure: Underlying neurobiology and its use in the study of obesity in animal models.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2018Review
- Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight.The Journal of clinical investigation · 2017Article
- Article
- Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- GLP-1 and weight loss: unraveling the diverse neural circuitry.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Exendin-4 (Ex4), a glucagon-like peptide-1 receptor (GLP-1R) agonist approved to treat type 2 diabetes mellitus, is well known to induce hypophagia in human and animal models. We evaluated the contributions of the hindbrain parabrachial nucleus (PBN) to systemic Ex4-induced hypophagia, as the PBN receives gustatory and visceral afferent relays and descending input from several brain nuclei associated with feeding. Rats with ibotenic-acid lesions targeted to the lateral PBN (PBNx) and sham controls received Ex4 (1 μg/kg) before 24 h home cage chow or 90 min 0.3 M sucrose access tests, and licking microstructure was analyzed to identify components of feeding behavior affected by Ex4. PBN lesion efficacy was confirmed using conditioned taste aversion (CTA) tests. As expected, sham control but not PBNx rats developed a CTA. In sham-lesioned rats, Ex4 reduced chow intake within 4 h of injection and sucrose intake within 90 min. PBNx rats did not show reduced chow or sucrose intake after Ex4 treatment, indicating that the PBN is necessary for Ex4 effects under the conditions tested. In sham-treated rats, Ex4 affected licking microstructure measures associated with hedonic taste evaluation, appetitive behavior, oromotor coordination, and inhibitory postingestive feedback. Licking microstructure responses in PBNx rats after Ex4 treatment were similar to sham-treated rats with the exception of inhibitory postingestive feedback measures. Together, the results suggest that the PBN critically contributes to the hypophagic effects of systemically delivered GLP-1R agonists by enhancing visceral feedback.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.