ArticleTalanta2015
Gold nanorod biochip functionalization by antibody thiolation.
Article in Talanta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Preparation of Nanoparticle-Immobilized Gold Surfaces for the Reversible Conjugation of Neurotensin Peptide.Biomolecules · 2025Article
- Selective enhanced cytotoxicity of amino acid deprivation for cancer therapy using thermozyme functionalized nanocatalyst.Journal of nanobiotechnology · 2024Article
- SCORe: SARS-CoV-2 Omicron Variant RBD-Binding DNA Aptamer for Multiplexed Rapid Detection and Pseudovirus Neutralization.Analytical chemistry · 2022Article
- Peroxidase-Mimicking Activity of Biogenic Gold Nanoparticles Produced fromACS applied bio materials · 2022Article
- Photostability of Contrast Agents for Photoacoustics: The Case of Gold Nanorods.Nanomaterials (Basel, Switzerland) · 2021Review
- Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications.Biosensors · 2020Review
- Speckle Noise Removal in Image-based Detection of Refractive Index Changes in Porous Silicon Microarrays.Scientific reports · 2019Article
- Label-Free Electrochemical Detection ofMicromachines · 2019Article
- Peptide Functionalization of Gold Nanoparticles for the Detection of Carcinoembryonic Antigen in Blood Plasma via SPR-Based Biosensor.Frontiers in chemistry · 2019Article
- Wash-free, label-free immunoassay for rapid electrochemical detection of PfHRP2 in whole blood samples.Scientific reports · 2018Article
- Image Processing of Porous Silicon Microarray in Refractive Index Change Detection.Sensors (Basel, Switzerland) · 2017Article
- Comparison of four methods for the biofunctionalization of gold nanorods by the introduction of sulfhydryl groups to antibodies.Beilstein journal of nanotechnology · 2017Article
- Gold Nanorod Array Biochip for Label-Free, Multiplexed Biological Detection.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Water dispersion of magnetic nanoparticles with selective Biofunctionality for enhanced plasmonic biosensing.Talanta · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Conjugation of biomolecules on gold nanorod (GNR) surfaces is the basis for successful applications in biosensing, imaging, and drug delivery. Current functionalization methods are often problematic, involving multi-step nanoparticle modification to replace surfactant bilayer, delicate nanoparticle protection during surfactant exchange, and material loss due to inevitable aggregation. Instead of intensive surface modification of GNRs, we describe herein a facile method to functionalize gold nanorod surfaces via covalent Au-S bonds by thiolating receptors. The resulting GNR-bioconjugates showed superior dispersion and stability in buffer for months without morphology change and aggregation. ELISA tests confirmed the high biofunctionality of the thiolated anti-IgG moieties immobilized on the GNR surfaces. Furthermore, this simple method facilitated a straightforward functionalization of GNR assembly on glass substrate to construct a specific biochip, which can detect human IgG targets in a label-free fashion with high sensitivity and specificity. Compared to electropolymeric coating to functionalize the GNR, our method exhibited a five-fold enhancement in the spectral sensitivity to refractive index change caused by the target binding. This universal GNR bioconjugation method can be extended to bind different proteins and antibodies for development of biosensors or drug delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.