Evidence map›Paper›PMID 25702770›Full record

ArticleAlcoholism, clinical and experimental research2015

Ethnic differences in presentation and severity of alcoholic liver disease.

Robert Levy, Andreea M Catana, Blythe Durbin-Johnson, Charles H Halsted, Valentina Medici

Open access · greenAbstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Acute alcohol-associated hepatitis: Latest findings in non-invasive biomarkers and treatment.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
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  20. Alcohol-related hepatitis: A review article.World journal of gastroenterology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Robert Levy *Department of Internal Medicine, University of California Davis, Division of Gastroenterology and Hepatology, University of California Davis.
Andreea M Catana *Department of Internal Medicine, University of California Davis, Division of Gastroenterology and Hepatology, University of California Davis.
Blythe Durbin-JohnsonDepartment of Public Health Sciences, Division of Biostatistics, University of California Davis.
Charles H HalstedDepartment of Internal Medicine, University of California Davis, Division of Gastroenterology and Hepatology, University of California Davis.
Valentina MediciDepartment of Internal Medicine, University of California Davis, Division of Gastroenterology and Hepatology, University of California Davis.
University of California, Davis · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
UC Davis Clinical and Translational Science CenterUL1TR000002 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$12.2M
Wilson Disease: Regulation of Steatosis by Methionine MetabolismK08DK084111 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MEDICI, VALENTINA · 2010 to 2014
$765k
Wilson Disease: Effect of High-Choline Feeding on Fetal and Offspring Mouse LiverR03DK099427 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MEDICI, VALENTINA · 2014 to 2015
$156k
Epigenetic regulation of alcoholic steatohepatitis in a mouse modelR03AA020577 · NIAAA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HALSTED, CHARLES HOPKINSON · 2011 to 2012
$154k
NCATS NIH HHS UL1 TR000002NIAAA NIH HHS R03 AA020577NIAAA NIH HHS R03AA020577-01NIDDK NIH HHS K08 DK084111NIDDK NIH HHS K08DK084111NIDDK NIH HHS P30 DK026743NIDDK NIH HHS R03 DK099427NIDDK NIH HHS R03DK099427
6 · The paper itself

Abstract

backgroundThe frequency of alcoholic liver disease (ALD), including alcoholic steatosis, hepatitis, and cirrhosis, varies significantly by ethnicity.

methodsWith the goal to assess the role of ethnicity in determining the age of onset and severity of ALD and to compare the risk factors for its progression among ethnic groups, we conducted a retrospective chart review of all patients with ALD who were admitted or were followed as outpatients at University of California Davis Medical Center between 2002 and 2010. After excluding HBsAg- and HIV-positive subjects, we reviewed the charts of 791 patients with ALD including 130 with alcoholic fatty liver, 154 with alcoholic hepatitis, and 507 with alcoholic cirrhosis.

resultsWhen controlling for all variables in the model, Hispanic patients presented at significantly 4 to 10 years younger ages than White/Caucasian patients, in each of the 3 disease severity categories, and the results were confirmed after excluding HCV Ab-/RNA-positive subjects. There were more obese Hispanic patients than White/Caucasian patients, whereas the proportion of patients with hepatitis C was significantly greater in African American subjects with alcoholic hepatitis, and the proportion of patients with diabetes mellitus was significantly lower in White/Caucasian subjects than in Hispanic subjects with cirrhosis. The proportion of subjects with severe alcoholic hepatitis was similar in Hispanic and White/Caucasian patients, but lower in African American subjects.

conclusionsEthnicity is a major factor affecting the age and severity of presentation of different subtypes of ALD.

Indexed as

Severity of Illness IndexEthnicityFemaleHumansLiver Diseases, AlcoholicMaleMiddle AgedRetrospective StudiesAlcoholicAlcoholic Liver DiseaseEthnicityHispanic

Identifiers

PMID25702770
PMCPMC4348235
OpenAlexW2145424614

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.