ArticleAging cell2015
Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae.
Article in Aging cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 62 citations in OpenAlex.
- The evolution of ageing: classic theories and emerging ideas.Biogerontology · 2024Review
- Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts.PLoS biology · 2024Article
- The chromatin accessibility and transcriptomic landscape of the aging mice cochlea and the identification of potential functional super-enhancers in age-related hearing loss.Clinical epigenetics · 2024Article
- The Activity of YCA1 Metacaspase Is Regulated by Reactive Sulfane Sulfur via Persulfidation inAntioxidants (Basel, Switzerland) · 2024Article
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- Unraveling Histone Loss in Aging and Senescence.Cells · 2024Review
- The Information Theory of Aging.Nature aging · 2023Review
- Dietary change without caloric restriction maintains a youthful profile in ageing yeast.PLoS biology · 2023Article
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- Phenotypic plasticity as a facilitator of microbial evolution.Environmental epigenetics · 2022Review
- Molecular Damage in Aging.Nature aging · 2021Review
- Modeling aging and its impact on cellular function and organismal behavior.Experimental gerontology · 2021Review
- Review
- The Evolution of the Hallmarks of Aging.Frontiers in genetics · 2021Review
- Transcriptomic and genomic changes associated with radioadaptation inComputational and structural biotechnology journal · 2021Article
- Article
- A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells.Aging cell · 2020Article
- Transcription-induced formation of extrachromosomal DNA during yeast ageing.PLoS biology · 2019Article
- Article
- Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The concept that mutations cause aging phenotypes could not be directly tested previously due to inability to identify age-related mutations in somatic cells and determine their impact on organismal aging. Here, we subjected Saccharomyces cerevisiae to multiple rounds of replicative aging and assessed de novo mutations in daughters of mothers of different age. Mutations did increase with age, but their low numbers, < 1 per lifespan, excluded their causal role in aging. Structural genome changes also had no role. A mutant lacking thiol peroxidases had the mutation rate well above that of wild-type cells, but this did not correspond to the aging pattern, as old wild-type cells with few or no mutations were dying, whereas young mutant cells with many more mutations continued dividing. In addition, wild-type cells lost mitochondrial DNA during aging, whereas shorter-lived mutant cells preserved it, excluding a causal role of mitochondrial mutations in aging. Thus, DNA mutations do not cause aging in yeast. These findings may apply to other damage types, suggesting a causal role of cumulative damage, as opposed to individual damage types, in organismal aging.
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