ArticleCurrent biology : CB2015
Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing.
Article in Current biology : CB, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.
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138 citing papers in PubMed, 285 citations in OpenAlex.
- Insulin receptor signaling in gustatory cells suppresses sugar taste sensitivity and feeding iniScience · 2026Article
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- A Comprehensive Molecular and Evolutionary Characterization of Chemosensory-Related Genes inAnimals : an open access journal from MDPI · 2026Article
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- Hugin-AstA circuitry is a novel central energy sensor that directly regulates sweet sensation ineLife · 2026Article
- Pleiotropic Cholesterol Signaling inMetabolites · 2026Review
- Expanding the sensory horizon: chemosensory receptors beyond traditional olfactory and taste organs in insects.Science China. Life sciences · 2026Review
- Transcriptome Analysis of the Brain and Gnathal Ganglion Reveals Feeding-Mediated Genes inBiomolecules · 2026Article
- Activity and State-Dependent Modulation of Salt Taste Behavior Via Pharyngeal Neurons inNeuroscience insights · 2026Article
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- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Multilayer regulation underlies the functional precision and evolutionary potential of the olfactory system.Nature communications · 2025Article
- Gal4 drivers of the geosmin receptor Or56a exhibit ectopic expression in the labral sense organ of Drosophila.Scientific reports · 2025Article
- Connectomics Reveals a Feed-Forward Swallowing Circuit Driving Protein Appetite.bioRxiv : the preprint server for biology · 2025Article
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- Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila.Scientific reports · 2025Article
- How Sugar Quality and Concentration Influence Oviposition Preference in Drosophila Melanogaster.Journal of chemical ecology · 2025Article
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- Evolutionary Process Underlying Receptor Gene Expansion and Cellular Divergence of Olfactory Sensory Neurons in Honeybees.Molecular biology and evolution · 2025Article
- Molecular evolution of gustatory receptors in the Anopheles gambiae complex.BMC ecology and evolution · 2025Article
78 more citing papers are in PubMed but not listed here.
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6 authors at 1 institution in 1 country.
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Abstract
Identification of nutritious compounds is dependent on expression of specific taste receptors in appropriate taste-cell types [1]. In contrast to mammals, which rely on a single, broadly tuned heterodimeric sugar receptor [2], the Drosophila genome harbors a small subfamily of eight, closely related gustatory receptor (Gr) genes, Gr5a, Gr61a, and Gr64a-Gr64f, of which three have been proposed to mediate sweet taste [3-6]. However, expression and function of several of these putative sugar Gr genes are not known. Here, we present a comprehensive expression and functional analysis using Gr(LEXA/GAL4) alleles that were generated through homologous recombination. We show that sugar Gr genes are expressed in a combinatorial manner to yield at least eight sets of sweet-sensing neurons. Behavioral investigations show that most sugar Gr mutations affect taste responses to only a small number of sugars and that effective detection of most sugars is dependent on more than one Gr gene. Surprisingly, Gr64a, one of three Gr genes previously proposed to play a major role in sweet taste [3, 4], is not expressed in labellar taste neurons, and Gr64a mutant flies exhibit normal sugar responses elicited from the labellum. Our analysis provides a molecular rationale for distinct tuning profiles of sweet taste neurons, and it favors a model whereby all sugar Grs contribute to sweet taste. Furthermore, expression in olfactory organs and the brain implies novel roles for sugar Gr genes in olfaction and internal nutrient sensing, respectively. Thus, sugar receptors may contribute to feeding behavior via multiple sensory systems.
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