ReviewCanadian journal of psychiatry. Revue canadienne de psychiatrie2014
Persistence and adherence with dementia pharmacotherapy: relevance of patient, provider, and system factors.
Review in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Access to healthcare services and adherence to treatments for people with dementia among ethnic minority groups: a scoping review.Frontiers in dementia · 2026Pooled it
- Persistence with anti-dementia medications: a systematic review and meta-analysis.Age and ageing · 2025Pooled it
- Improving medication adherence among community-dwelling seniors with cognitive impairment: a systematic review of interventions.International journal of clinical pharmacy · 2017Pooled it
- Formulation and Optimization of Memantine-Loaded PEGylated Single-Walled Carbon Nanotube Dispersions.AAPS PharmSciTech · 2025Article
- Inequalities in the Quality and Safety of Post-Diagnostic Primary Care for People With Dementia: A Scoping Review.International journal of geriatric psychiatry · 2024Article
- Trajectories of oral bisphosphonate use after hip fractures: a population-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Observational
- Non-adherence to antidementia medications and associated factors: a study of Spanish population-based registry data.Frontiers in pharmacology · 2024Article
- Specialist Availability and Drug Adherence in Older Adults with Dementia Across Regions of the United States.Journal of Alzheimer's disease : JAD · 2023Article
- Lack of Any Caregiving for Those with Dementia.Journal of Alzheimer's disease : JAD · 2022Article
- Role of caregivers on medication adherence management in polymedicated patients with Alzheimer's disease or other types of dementia.Frontiers in public health · 2022Observational
- CCCDTD5 recommendations on the deprescribing of cognitive enhancers in dementia.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Pharmacokinetic Evaluation of a Novel Donepezil-Loaded Dissolving Microneedle Patch in Rats.Pharmaceutics · 2021Article
- Discontinuation Rate of Newly Prescribed Donepezil in Alzheimer's Disease Patients in Asia.Journal of clinical neurology (Seoul, Korea) · 2021Article
- Adverse Drug Reactions of Acetylcholinesterase Inhibitors in Older People Living with Dementia: A Comprehensive Literature Review.Therapeutics and clinical risk management · 2021Review
- Resident-Level Predictors of Dementia Pharmacotherapy at Long-Term Care Admission: The Impact of Different Drug Reimbursement Policies in Ontario and Saskatchewan: Prédicteurs de la pharmacothérapie de la démence au niveau des résidents lors de l'hospitalisation dans des soins de longue durée : l'impact de différentes politiques de remboursement des médicaments en Ontario et en Saskatchewan.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
- Persistence and adherence to rivastigmine in patients with dementia: Results from a noninterventional, retrospective study using the National Health Insurance research database of Taiwan.Alzheimer's & dementia (New York, N. Y.) · 2019Article
- Persistence With Oral Antihyperglycemic Drugs in Type 2 Diabetes Mellitus Patients With Dementia in Germany.Journal of diabetes science and technology · 2018Article
- Persistence with antihypertensives in uncomplicated treatment-naïve very elderly patients: a nationwide population-based study.BMC cardiovascular disorders · 2017Article
- Disparities in pharmacotherapy for alcohol use disorder in the context of universal health care: a Swedish register study.Addiction (Abingdon, England) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper provides a comprehensive review of studies examining adherence and (or) persistence with dementia pharmacotherapy during the past decade, including a summary of the key patient-, drug-, system-, and provider-level factors associated with these measures. Estimates of adherence and 1-year persistence to these drugs have ranged from 34% to 94% and 35% to 60%, respectively. Though many studies reported nonsignificant associations, there are data suggesting that patient age, sex, ethnoracial background, socioeconomic status, and region-specific reimbursement criteria, as well as the extent and quality of interactions among patients, caregivers, and providers, may influence persistence with pharmacotherapy. As many studies relied on administrative data, limited information was available regarding the relevance of patient's cognitive and functional status or the importance of caregiver involvement or assistive devices to adherence or persistence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.