Evidence map›Paper›PMID 25702320›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2015

Characterization of ventricular assist device-mediated sensitization in the bridge-to-heart-transplantation patient.

Murray H Kwon, Jennifer Q Zhang, Joanna M Schaenman, Martin Cadeiras, David W Gjertson, Carolyn A Krystal, Hillel Laks, Abbas Ardehali, Mario C Deng, Richard J Shemin and 1 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Impact of Previous Conventional Cardiac Surgery on the Clinical Outcomes After Heart Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  3. Article
  4. Ventricular assist device elicits serum natural IgG that correlates with the development of primary graft dysfunction following heart transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2017
    Article
  5. Desensitization Strategies Pre- and Post-Cardiac Transplantation.Current treatment options in cardiovascular medicine · 2016
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Murray H KwonDivision of Cardiothoracic Surgery, Department of Surgery, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, Calif. Electronic address: mkwon@mednet.ucla.edu.
Jennifer Q ZhangUniversity of California, Los Angeles Immunogenetics Center, University of California, Los Angeles, Los Angeles, Calif.
Joanna M SchaenmanDivision of Immunology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, Calif.
Martin CadeirasDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, Calif.
David W GjertsonUniversity of California, Los Angeles Immunogenetics Center, University of California, Los Angeles, Los Angeles, Calif.
Carolyn A KrystalDavid Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, Calif.
Hillel LaksDivision of Cardiothoracic Surgery, Department of Surgery, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, Calif.
Abbas ArdehaliDivision of Cardiothoracic Surgery, Department of Surgery, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, Calif.
Mario C DengDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, Calif.
Richard J SheminDivision of Cardiothoracic Surgery, Department of Surgery, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, Calif.
Elaine F ReedUniversity of California, Los Angeles Immunogenetics Center, University of California, Los Angeles, Los Angeles, Calif.
University of California, Los Angeles · US

Funding

Anti-MHC Effects on EndotheliumR01AI042819 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REED, ELAINE F · 1999 to 2014
$4.0M
NIAID NIH HHS R01 AI042819
6 · The paper itself

Abstract

objectiveVentricular assist devices (VADs) are associated with increased anti-human leukocyte antigen antibody production. The purpose of this study is to characterize differences in sensitization patterns in patients receiving axial flow, implantable VADs versus pulsatile, paracorporeal biventricular assist devices (BIVADs) as bridges to transplantation.

methodsThe study is a retrospective review of 68 patients who were bridged to transplantation with either a VAD or a BIVAD, as described, from January 2007 to June 2010, at a university medical center.

resultsFive of 15 (33.3%) VAD patients became sensitized during treatment, compared with 30 of 53 (56.6%) BIVAD patients, P = .15. Multivariable analysis comparing BIVAD with VAD, while controlling for previous cardiac surgery, pregnancy, and packed red blood cell transfusion produced an odds ratio of 2.99, P = .14. Of sensitized patients, all 5 (100%) of the VAD patients had pre-existing antibodies before VAD placement, compared with 9 of 30 (30.0%) BIVAD patients, P = .006. Maximum cumulative mean fluorescence intensities for BIVAD were 46,259 ± 66,349 versus 42,540 ± 12,840 for VAD, P = .90. Time to maximum antibody expression was shorter for the VAD group (34 ± 28 days vs 5.8 ± 9 days, P = .04).

conclusionsDevice type was not a factor in patient sensitization after implantation. However, VAD patients required pre-existing sensitization before implantation to produce antibodies during their treatment interval, whereas more than two thirds of BIVAD patients developed de novo antibodies. These data suggest that the mechanism of sensitization between VAD and BIVAD patients may differ, and further mechanistic studies into the impact of device types on patient sensitization are warranted.

Indexed as

Heart-Assist DevicesHeart TransplantationVentricular Function, LeftVentricular Function, RightWaiting ListsAcademic Medical CentersAdolescentAdultAgedAutoantibodiesChi-Square DistributionFemaleHeart FailureHLA AntigensHumansLos AngelesAutoantibodiesHLA Antigens

Identifiers

PMID25702320
PMCPMC7130105
OpenAlexW2157404152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.