ArticleAnalytica chimica acta2015
Direct drug analysis from oral fluid using medical swab touch spray mass spectrometry.
Article in Analytica chimica acta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 80 citations in OpenAlex.
- Metabolite ratiomics: Rapid diagnosis and classification of gliomas for intraoperative application during brain surgery.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Untargeted Swab Touch Spray-Mass Spectrometry Analysis with Machine Learning for On-Site Breast Surgical Margin Assessment.Analytical chemistry · 2025Article
- Influence of Solvent Relative Permittivity in Swab Spray Mass Spectrometry.Molecules (Basel, Switzerland) · 2024Article
- Analysis of Pesticide Residues on Fruit Using Swab Spray Ionization Mass Spectrometry.Molecules (Basel, Switzerland) · 2023Article
- Spherical Sampler Probes Enhance the Robustness of Ambient Ionization Mass Spectrometry for Rapid Drugs Screening.Molecules (Basel, Switzerland) · 2022Article
- Direct adsorption sampling and ambient mass spectrometry analysis of tobacco smoke with porous paper strips.Frontiers in chemistry · 2022Article
- The Relevance of Mass Spectrometry Analysis for Personalized Medicine through Its Successful Application in Cancer "Omics".International journal of molecular sciences · 2019Review
- Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry.Journal of food and drug analysis · 2019Article
- Direct sampling mass spectrometry for clinical analysis.The Analyst · 2019Review
- Fatty Acid Patterns Detected By Ambient Ionization Mass Spectrometry in Canine Invasive Urothelial Carcinoma From Dogs of Different Breeds.Bladder cancer (Amsterdam, Netherlands) · 2018Article
- Precursor and Neutral Loss Scans in an RF Scanning Linear Quadrupole Ion Trap.Journal of the American Society for Mass Spectrometry · 2018Article
- New Advances in Toxicological Forensic Analysis Using Mass Spectrometry Techniques.Journal of analytical methods in chemistry · 2018Review
- Analysis of human gliomas by swab touch spray-mass spectrometry: applications to intraoperative assessment of surgical margins and presence of oncometabolites.The Analyst · 2017Article
- Ionization Suppression and Recovery in Direct Biofluid Analysis Using Paper Spray Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2016Article
- Miniature and Fieldable Mass Spectrometers: Recent Advances.Analytical chemistry · 2016Review
- Ambient Ionization Mass Spectrometry for Point-of-Care Diagnostics and Other Clinical Measurements.Clinical chemistry · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Fourteen common drugs of abuse were identified in spiked oral fluid (ng mL(-1) levels), analyzed directly from medical swabs using touch spray mass spectrometry (TS-MS), exemplifying a rapid test for drug detection. Multiple stages of mass analysis (MS(2) and MS(3)) provided identification and detection limits sought by international forensic and toxicological societies, Δ(9)-THC and buprenorphine excluded. The measurements were made using a medical swab as both the sampling probe and means of ionization. The adaptation of medical swabs for TS-MS analysis allows non-invasive and direct sampling of neat oral fluid. Data acquisition was rapid, seconds per drug, and MS(3) ensured reliable identification of illicit drugs. The reported data were acquired to investigate (i) ionization of common drugs from commercial swabs, (ii) ion intensity over spray duration, and (iii) dynamic range, all as initial steps in development of a quantitative method. The approach outlined is intended for point-of-care drug testing using oral fluid in clinical applications as well as in situ settings, viz. in forensic applications. The proof-of-concept results presented will require extension to other controlled substances and refinement in analytical procedures to meet clinical/legal requirements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.